调控神经干细胞增殖分化重要细胞因子的研究进展
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摘要
目前神经干细胞的自我更新能力和多分化潜能越来越受到人们的关注,这种特性使得其能够促进神经系统的修复和损伤后脑部功能的恢复,故神经干细胞称为临床治疗神经系统疾病的种子细胞之一。本文就影响神经干细胞增殖与分化的一些重要细胞因子的研究进展进行综述。
At present, the self-renewal ability and multi-differentiation potential of neural stem cells have been paid more and more attention, which makes them promote the repair of nervous system and the recovery of brain function after injury. So neural stem cells are one of the seed cells for clinical treatment of nervous system diseases. This article reviews the research progress of some important cytokines that affect the proliferation and differentiation of neural stem cells.
At present, the self-renewal ability and multi-differentiation potential of neural stem cells have been paid more and more attention, which makes them promote the repair of nervous system and the recovery of brain function after injury. So neural stem cells are one of the seed cells for clinical treatment of nervous system diseases. This article reviews the research progress of some important cytokines that affect the proliferation and differentiation of neural stem cells.
引文
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[3] Puttonen KA, Ruponen M, Kauppinen R, et al. Improved method of producing human neural progenitor cells of high purity and in large quantities from pluripotent stem cells for transplantation studies[J]. Cell Transpla nt,2013,22(10):1753-1766.
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[11] Song S, Park JT, Na JY, et al. Early expressions of hypoxia-inducible factor1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia[J].Neural Regen Res,2014(9):912-918.
[12] Meng H, Zhang Z, Zhang R, et al. Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenit ors[J]. Neurosci Lett,2006,393(2-3):97-101.
[13] Sun J, Zhou W, Ma D, et al. Endothelial cells promote neural stem cell proliferation and differentiation associated with VEGF activated Notch and Pten signaling[J]. Dev Dyn,2010,239(9):2345-53.
[14] Sun JQ, Sha B, Zhou WH, et a1. Basic fibroblast growth factor stimulat es the prolif eration and diff erentiation of neural stem cells in neonat al rats aft er ischemic brain injury[J]. BrainDev,2009,31(5):331-340.
[15]郭雨霁,李盛芳.神经营养因子家族及其受体的研究进展[J].神经解剖学杂志,2001,17(3):288-294.
[16] Xu ZQ, Li J, Deng J, et al. Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer’ disease rat model[J]. Zhonghua Yi Xue Za Zhi. 2010,90(19):1353-1356.
[17] Hempstead BL. Dissecting the diverse actions of pro and mature neurotrophins[J].Curr Alzheimer Res,2006,3(1):19-24.
[18] Ascano M, Bodmer D, Kuruvilla R. Endocytic trafficking of neurotrophins in neural development[J]. Trends Cell Biol,2012,22(5):266-273.
[19] Lin Y, Wan JQ, Gao GY, et al. Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat[J].Biomaterials,2015,69:148-157.
[20] BardeYA, EdgarD, ThoenenH, et al. Purification of a new neurotrophic factor from mammalian brain[J]. EMBOJ,1982,1:549-553.
[21] Foltran RB, Diaz SL. BDNF isoforms:a round trip ticket between neurogenesis and serotonin[J]. Neurochem,2016,138(2):204-221.
[22] Pencea V, Bingaman KD, Wiegand SJ, et al. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus[J]. Neurosci,2001,21(17):6706-6717.
[23] Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 chemokine axis:a potential therapeutic target for bone metastases[J]. Curr Pharm Des,2010,16(11):1284-1290.
[24] Schnemeier B, Kolodziej A, Schulz S, et al. Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain[J]. Comp Neurol,2008,510(2):207-220.
[25] Gong X, He X, Qi L, et al. Stromal cell derived factor-1 acutely promotes neural progenitor cell proliferation in vitro by a mechanism involving the ERK1/2 and PI-3K signal pathways[J].Cell Biol Int,2006,30(5):466-471.
[26] Li GQ, Xie J, Lei XY, et al. Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway[J].World J Gastroenterol,2009,15(44):5541-5548.
[27] Wu Y, Peng H, Cui M, et al. CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway[J]. Neuroch em,2009,109(4):1157-1167.
[28] Peng H, Kolb R, Kennedy JE, et al. Differential expression of CXCL12and CXCR4 during human fetal neural progenitor cell differentiation[J].Neuroimmune Pharmacol,2007,2(3):251-258.
[29] Pujol F, Kitabgi P, Boudin H. The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons[J]. Cell Sci,2005,118(5):1071-1080.
[30] Moses D, Teper Y, Gantois I, et al. Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons[J]. Exp Neurol,2006,18(1):4-8.
[31] SAHAY A, HEN R. Adult hippocampal neurogenesis in depression[J].Nature Neuroscience,2007,10(9):1110-1115.
[32] FREEN H F, TREACY E, KEOHANE A K, et al.A role for interleukin-1βin determining the lineage fate of embryonic rat hippocampal neural precursor cells[J]. Molecular and Cellular Neuroscience,2012,49:311-321.
[33] GOSHEN I, KREISEL T, BENMZO, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression[J].Mol Psychiatry,2008,13:717-728.
[34] Kaneko N, Kudo K, Mabuchi T, et al. Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus[J]. Neuropsychopharmacology, 2006,31(12):2619-26.
[35] Yuxian, Shi Rui, Yang Hailan. Effect of IFN-γon the development of embryonic neural stem cells. Cardiovascular Disease Journal of integrated traditional Chinese and Western Medicine,2012,8(5):591-592.
[36] Lan X, Chen Q, Wang Y, et al. TNF alpha affects human cortical neural progenitor cell differentiation through the autocrine secretion of leukemia inhibitory factor[J]. PLoS One,2012,7(12):e50783.
[37] Yuan Lili, Jiang Haiyan, Dengdian, et al. Study of anti-apoptotic effect of erythropoietin on the cultured NSCs from brain cortex of embryonic rats in vitro[J]. Jining Medical College,2011,34(2):77-80.
[2] Fuentealba LC, Obernier K, Alvarez-Buylla A. Adult neural stem cells bridge their niche[J]. Cell Stem Cell,2012,10(6):698-708.
[3] Puttonen KA, Ruponen M, Kauppinen R, et al. Improved method of producing human neural progenitor cells of high purity and in large quantities from pluripotent stem cells for transplantation studies[J]. Cell Transpla nt,2013,22(10):1753-1766.
[4]刘珍,武衡,谢明.神经干细胞及其应用研究新进展[J].社区医学杂志,2011,9(02):41-42.
[5]张莉莉,李玉坤.生长因子对骨代谢影响的研究进展[J].国际药学研究杂志,2012,39(02):121-126.
[6] Duan H, Ge W, Zhang A, et al. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury[J]. Proc Natl Acad Sci USA,2015,112(43):13360-13365.
[7] Palmer TD, Markakis EA, Willhoite AR, et al. Fibroblast growth factor-2activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS[J]. J Neurosci,1999,19(19):8487-8497.
[8] Carmeliet P. Blood vessels and nerves:common signals, pathways and diseases[J]. Nat Rev Genet,2003,4(9):710-720.
[9] CHOI JW, KIM S, KIM TM, et al. Basic fibroblast growth factor activates MEK/ERK cell signaling pathway and stimulates the proliferation of chicken primordial germ cells[J]. Plos One,2010,5(9):e12968.
[10] Rosenstein JM, Krum JM, Ruhrberg C. VEGF in the nervous system[J]. Org anogenesis,2010,6(2):107-114.
[11] Song S, Park JT, Na JY, et al. Early expressions of hypoxia-inducible factor1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia[J].Neural Regen Res,2014(9):912-918.
[12] Meng H, Zhang Z, Zhang R, et al. Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenit ors[J]. Neurosci Lett,2006,393(2-3):97-101.
[13] Sun J, Zhou W, Ma D, et al. Endothelial cells promote neural stem cell proliferation and differentiation associated with VEGF activated Notch and Pten signaling[J]. Dev Dyn,2010,239(9):2345-53.
[14] Sun JQ, Sha B, Zhou WH, et a1. Basic fibroblast growth factor stimulat es the prolif eration and diff erentiation of neural stem cells in neonat al rats aft er ischemic brain injury[J]. BrainDev,2009,31(5):331-340.
[15]郭雨霁,李盛芳.神经营养因子家族及其受体的研究进展[J].神经解剖学杂志,2001,17(3):288-294.
[16] Xu ZQ, Li J, Deng J, et al. Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer’ disease rat model[J]. Zhonghua Yi Xue Za Zhi. 2010,90(19):1353-1356.
[17] Hempstead BL. Dissecting the diverse actions of pro and mature neurotrophins[J].Curr Alzheimer Res,2006,3(1):19-24.
[18] Ascano M, Bodmer D, Kuruvilla R. Endocytic trafficking of neurotrophins in neural development[J]. Trends Cell Biol,2012,22(5):266-273.
[19] Lin Y, Wan JQ, Gao GY, et al. Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat[J].Biomaterials,2015,69:148-157.
[20] BardeYA, EdgarD, ThoenenH, et al. Purification of a new neurotrophic factor from mammalian brain[J]. EMBOJ,1982,1:549-553.
[21] Foltran RB, Diaz SL. BDNF isoforms:a round trip ticket between neurogenesis and serotonin[J]. Neurochem,2016,138(2):204-221.
[22] Pencea V, Bingaman KD, Wiegand SJ, et al. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus[J]. Neurosci,2001,21(17):6706-6717.
[23] Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 chemokine axis:a potential therapeutic target for bone metastases[J]. Curr Pharm Des,2010,16(11):1284-1290.
[24] Schnemeier B, Kolodziej A, Schulz S, et al. Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain[J]. Comp Neurol,2008,510(2):207-220.
[25] Gong X, He X, Qi L, et al. Stromal cell derived factor-1 acutely promotes neural progenitor cell proliferation in vitro by a mechanism involving the ERK1/2 and PI-3K signal pathways[J].Cell Biol Int,2006,30(5):466-471.
[26] Li GQ, Xie J, Lei XY, et al. Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway[J].World J Gastroenterol,2009,15(44):5541-5548.
[27] Wu Y, Peng H, Cui M, et al. CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway[J]. Neuroch em,2009,109(4):1157-1167.
[28] Peng H, Kolb R, Kennedy JE, et al. Differential expression of CXCL12and CXCR4 during human fetal neural progenitor cell differentiation[J].Neuroimmune Pharmacol,2007,2(3):251-258.
[29] Pujol F, Kitabgi P, Boudin H. The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons[J]. Cell Sci,2005,118(5):1071-1080.
[30] Moses D, Teper Y, Gantois I, et al. Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons[J]. Exp Neurol,2006,18(1):4-8.
[31] SAHAY A, HEN R. Adult hippocampal neurogenesis in depression[J].Nature Neuroscience,2007,10(9):1110-1115.
[32] FREEN H F, TREACY E, KEOHANE A K, et al.A role for interleukin-1βin determining the lineage fate of embryonic rat hippocampal neural precursor cells[J]. Molecular and Cellular Neuroscience,2012,49:311-321.
[33] GOSHEN I, KREISEL T, BENMZO, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression[J].Mol Psychiatry,2008,13:717-728.
[34] Kaneko N, Kudo K, Mabuchi T, et al. Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus[J]. Neuropsychopharmacology, 2006,31(12):2619-26.
[35] Yuxian, Shi Rui, Yang Hailan. Effect of IFN-γon the development of embryonic neural stem cells. Cardiovascular Disease Journal of integrated traditional Chinese and Western Medicine,2012,8(5):591-592.
[36] Lan X, Chen Q, Wang Y, et al. TNF alpha affects human cortical neural progenitor cell differentiation through the autocrine secretion of leukemia inhibitory factor[J]. PLoS One,2012,7(12):e50783.
[37] Yuan Lili, Jiang Haiyan, Dengdian, et al. Study of anti-apoptotic effect of erythropoietin on the cultured NSCs from brain cortex of embryonic rats in vitro[J]. Jining Medical College,2011,34(2):77-80.
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