骨碎补总黄酮防治原发性骨质疏松症的研究进展
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摘要
骨质疏松症为常见的骨代谢疾病,随着社会老龄化加剧,其发病率亦逐年上升。近年来,传统中药防治骨质疏松症研究不断深入,研究发现,骨碎补及骨碎补总黄酮具有较明显的抗骨质疏松活性,能够通过有效地调节骨代谢及改善骨结构来发挥防治骨质疏松症的作用。本文从骨碎补总黄酮改善骨代谢及防治骨质疏松的细胞、动物、临床水平及相关通路研究进行综述,分析了目前研究概况及存在的问题,旨在为该药材防治骨质疏松症的深入研究及开发新的靶向治疗药物提供参考及借鉴。
Osteoporosis is a common bone metabolic disease. As the aggravation of social aging, its incidence rate is increasing year by year. In recent years, the traditional Chinese medicine prevention and treatment of loosening disease has been deepened, and it has been found that the flavonoids of Rhizoma Drynariae and its granules had obvious anti-osteoporosis activity, which could prevent osteoporosis by effectively regulating bone metabolism and improving bone structure. This article reviews the research on the cell, animal, clinical level and related pathways of bone granules to improve bone metabolism and prevent and treat osteoporosis,and analyzes the current research situation and existing problems. The aim of this work is to provide reference for the in-depth study of the medicinal materials for the prevention and treatment of osteoporosis and the development of new targeted therapeutic drugs.
Osteoporosis is a common bone metabolic disease. As the aggravation of social aging, its incidence rate is increasing year by year. In recent years, the traditional Chinese medicine prevention and treatment of loosening disease has been deepened, and it has been found that the flavonoids of Rhizoma Drynariae and its granules had obvious anti-osteoporosis activity, which could prevent osteoporosis by effectively regulating bone metabolism and improving bone structure. This article reviews the research on the cell, animal, clinical level and related pathways of bone granules to improve bone metabolism and prevent and treat osteoporosis,and analyzes the current research situation and existing problems. The aim of this work is to provide reference for the in-depth study of the medicinal materials for the prevention and treatment of osteoporosis and the development of new targeted therapeutic drugs.
引文
[1]刘敏燕,李春霖.老年骨质疏松症的防治策略及进展.中华老年多器官疾病杂志,2013,12(5):397-400
[2]Tohda C,Nagata A.Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury.Evid Based Comple Alternat Med,2012,7(9):731208
[3]李建国,谢兴文,李鼎鹏,等.中药淫羊藿治疗骨质疏松症的研究进展.中国骨质疏松杂志,2018,24(3):389-393
[4]李祥雨,姜劲挺,李建国,等.骨质疏松症中药防治研究进展.中国骨质疏松杂志,2018,24(2):270-275
[5]国家药典委员会编.中华人民共和国药典(2010年版一部).北京:中国医药科技出版社,2010:239-240
[6]李晋玉,赵学千,孙旗.骨碎补总黄酮的实验及临床研究概况.中国骨质疏松杂志,2018,24(10):1357-1364
[7]陈丽辉.骨碎补总黄酮(强骨胶囊)治疗老年骨质疏松症的效果及对骨密度的影响.临床合理用药杂志,2018,11(11):60-61
[8]史晓治,赵咏芳,郭海玲.骨碎补总黄酮与淫羊藿苷对人骨髓基质干细胞增殖及蛋白表达的影响.中医学报,2015,30(5):693-695
[9]舒晓春,刘君静,朱丹华,等.不同浓度的骨碎补总黄酮对大鼠骨髓间充质干细胞向成骨细胞分化的影响.中国病理生理杂志,2010,26(7):1261-1264
[10]罗伟东,姜自伟,李悦,等.牵张应力下骨碎补总黄酮对成骨细胞增殖及相关蛋白含量的影响.新中医,2016,48(8):299-302
[11]高怡加,黄培镇,李悦,等.骨碎补总黄酮对牵张成骨过程中骨形态发生蛋白-2和转化生长因子-β1表达的影响.广州中医药大学学报,2016,33(5):679-683
[12]Rosen V.BMP2 signaling in bone development and repai.Cytokine Growth Factor Rev,2009,20(5/6):475
[13]尹文哲,徐展望,王利,等.骨碎补总黄酮对模拟失重下共育骨细胞中ALP活性及BMP-2和OPG基因表达影响.中药材,2012,35(3):452-455
[14]黄晓菲,袁苏健,杨成.骨碎补总黄酮依赖PI3K/Akt通路与牙髓干细胞的成骨分化.中国组织工程研究,2013,17(1):92-97
[15]齐鹏飞,尹文哲,孙奇峰,等.失重下骨碎补总黄酮抑制JNK通路促间充质干细胞增殖的研究.中医学报,2016,31(11):1742-1745
[16]孙奇峰,尹文哲,高原,等.失重下骨碎补总黄酮经MAPK通路促间充质干细胞向成骨细胞分化研究.中医药学报,2016,44(4):10-13
[17]尹文哲,邢成亮,王建业,等.失重下骨碎补总黄酮经ERK通路促成骨细胞增殖研究.中医药学报,2017,45(5):45-48
[18]刘康,吴风晴,吴连国,等.骨碎补总黄酮对骨质疏松模型大鼠OPG/RANKL/RANK轴系统的影响.中国现代应用药学,2015,32(6):652-656
[19]姜自伟,曾景奇,黄枫,等.骨碎补总黄酮促进大鼠牵张成骨新骨形成的影像学研究.广州中医药大学学报,2017,34(3):390-393
[20]姜自伟,曾景奇,黄枫,等.骨碎补总黄酮对大鼠胫骨牵张成骨效能的影响.中华中医药杂志,2018,33(2):661-663
[21]上官文姬,李展春,程光齐,等.骨碎补总黄酮对绝经后骨质疏松大鼠疼痛介质和疼痛反应影响.辽宁中医药大学学报,2017,19(3):10-12
[22]曾辉,赵许兵,唐成芳,等.骨碎补总黄酮对去卵巢大鼠下颌骨密度及骨代谢生化指标的影响.口腔颌面修复学杂志,2018,19(3):171-175
[23]曾辉,赵许兵,徐红艳,等.骨碎补总黄酮对去卵巢大鼠下颌骨显微结构及最大载荷的影响.中国骨质疏松杂志,2018,24(4):520-525
[24]黄松,陈敬有,高皓.骨碎补总黄酮对骨质疏松症大鼠BMP-2蛋白表达及血清骨钙素水平的影响.中国当代医药,2017,24(4):12-15
[25]吴连国,倪力刚,刘康,等.骨碎补总黄酮对去卵巢模型大鼠RANKL、E2及骨矿含量影响的实验研究.中华中医药学刊,2013,31(12):2628-2630
[26]朱振标,林之斌,丁晓莉,等.骨碎补总黄酮对去卵巢大鼠RANKL/OPG平衡及MAPK信号通路的影响.海南医学,2015,26(9):1249-1253
[27]张新涛,江华基,梁祖儒,等.骨碎补总黄酮通过激活mTOR信号通路促进大鼠腱骨愈合的实验研究.中国骨伤,2018,31(3):248-253
[28]曾景奇.基于BMP-Smad通路探讨骨碎补总黄酮影响牵张成骨的初步研究.广州中医药大学博士论文,2016
[29]Lv J,Sun X,Ma J,et al.Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention ofneurectomy-induced bone loss by naringin.Biochem Biophys Res Commun,2015,468(4):587-593
[30]杨锋,孙玉华,吕中静,等.骨碎补总黄酮对骨质疏松症患者牙槽骨的影响.中国口腔颌面外科杂志,2018,16(1):34-40
[31]张春琪,刘鹏鹤.骨碎补总黄酮治疗绝经后女性骨质疏松症68例临床观察.中医临床研究,2015,7(28):103-104
[32]樊继波,覃勇,李莎,等.离子导入骨碎补总黄酮对骨质疏松症患者腰椎骨密度影响临床研究.中国骨质疏松杂志,2013,19(12):1256-1258
[33]丁小刚,覃勇,鄂建设,等.骨碎补总黄酮对老年性骨质疏松症患者血清骨钙素水平及骨密度影响.中国骨质疏松杂志,2013,19(5):519-521
[34]Zhang Y,Jiang J,Shen H,et al.Total flavonoids from Rhizoma Drynariae(Gusuibu)for treating osteoporotic fractures:implication in clinical practice.Drug Des Devel Ther,2017,11:1881-1890
[35]周瑞明,管义红,王全兵,等.强骨胶囊联合鹿瓜多肽注射液治疗老年原发性骨质疏松症的临床研究.现代药物与临床,2017,32(7):1337-1340
[36]韩亚力,罗奕,曾佳学.骨碎补总黄酮基于Notch信号通路改善骨质疏松的作用及机制研究.中国免疫学杂志,2018,34(2):261-266
[37]赖满香,廖利平,谭玮璐,等.“肾精-骨质疏松-骨髓间充质干细胞”理论探讨.中医杂志,2018,2(52):100-103
[2]Tohda C,Nagata A.Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury.Evid Based Comple Alternat Med,2012,7(9):731208
[3]李建国,谢兴文,李鼎鹏,等.中药淫羊藿治疗骨质疏松症的研究进展.中国骨质疏松杂志,2018,24(3):389-393
[4]李祥雨,姜劲挺,李建国,等.骨质疏松症中药防治研究进展.中国骨质疏松杂志,2018,24(2):270-275
[5]国家药典委员会编.中华人民共和国药典(2010年版一部).北京:中国医药科技出版社,2010:239-240
[6]李晋玉,赵学千,孙旗.骨碎补总黄酮的实验及临床研究概况.中国骨质疏松杂志,2018,24(10):1357-1364
[7]陈丽辉.骨碎补总黄酮(强骨胶囊)治疗老年骨质疏松症的效果及对骨密度的影响.临床合理用药杂志,2018,11(11):60-61
[8]史晓治,赵咏芳,郭海玲.骨碎补总黄酮与淫羊藿苷对人骨髓基质干细胞增殖及蛋白表达的影响.中医学报,2015,30(5):693-695
[9]舒晓春,刘君静,朱丹华,等.不同浓度的骨碎补总黄酮对大鼠骨髓间充质干细胞向成骨细胞分化的影响.中国病理生理杂志,2010,26(7):1261-1264
[10]罗伟东,姜自伟,李悦,等.牵张应力下骨碎补总黄酮对成骨细胞增殖及相关蛋白含量的影响.新中医,2016,48(8):299-302
[11]高怡加,黄培镇,李悦,等.骨碎补总黄酮对牵张成骨过程中骨形态发生蛋白-2和转化生长因子-β1表达的影响.广州中医药大学学报,2016,33(5):679-683
[12]Rosen V.BMP2 signaling in bone development and repai.Cytokine Growth Factor Rev,2009,20(5/6):475
[13]尹文哲,徐展望,王利,等.骨碎补总黄酮对模拟失重下共育骨细胞中ALP活性及BMP-2和OPG基因表达影响.中药材,2012,35(3):452-455
[14]黄晓菲,袁苏健,杨成.骨碎补总黄酮依赖PI3K/Akt通路与牙髓干细胞的成骨分化.中国组织工程研究,2013,17(1):92-97
[15]齐鹏飞,尹文哲,孙奇峰,等.失重下骨碎补总黄酮抑制JNK通路促间充质干细胞增殖的研究.中医学报,2016,31(11):1742-1745
[16]孙奇峰,尹文哲,高原,等.失重下骨碎补总黄酮经MAPK通路促间充质干细胞向成骨细胞分化研究.中医药学报,2016,44(4):10-13
[17]尹文哲,邢成亮,王建业,等.失重下骨碎补总黄酮经ERK通路促成骨细胞增殖研究.中医药学报,2017,45(5):45-48
[18]刘康,吴风晴,吴连国,等.骨碎补总黄酮对骨质疏松模型大鼠OPG/RANKL/RANK轴系统的影响.中国现代应用药学,2015,32(6):652-656
[19]姜自伟,曾景奇,黄枫,等.骨碎补总黄酮促进大鼠牵张成骨新骨形成的影像学研究.广州中医药大学学报,2017,34(3):390-393
[20]姜自伟,曾景奇,黄枫,等.骨碎补总黄酮对大鼠胫骨牵张成骨效能的影响.中华中医药杂志,2018,33(2):661-663
[21]上官文姬,李展春,程光齐,等.骨碎补总黄酮对绝经后骨质疏松大鼠疼痛介质和疼痛反应影响.辽宁中医药大学学报,2017,19(3):10-12
[22]曾辉,赵许兵,唐成芳,等.骨碎补总黄酮对去卵巢大鼠下颌骨密度及骨代谢生化指标的影响.口腔颌面修复学杂志,2018,19(3):171-175
[23]曾辉,赵许兵,徐红艳,等.骨碎补总黄酮对去卵巢大鼠下颌骨显微结构及最大载荷的影响.中国骨质疏松杂志,2018,24(4):520-525
[24]黄松,陈敬有,高皓.骨碎补总黄酮对骨质疏松症大鼠BMP-2蛋白表达及血清骨钙素水平的影响.中国当代医药,2017,24(4):12-15
[25]吴连国,倪力刚,刘康,等.骨碎补总黄酮对去卵巢模型大鼠RANKL、E2及骨矿含量影响的实验研究.中华中医药学刊,2013,31(12):2628-2630
[26]朱振标,林之斌,丁晓莉,等.骨碎补总黄酮对去卵巢大鼠RANKL/OPG平衡及MAPK信号通路的影响.海南医学,2015,26(9):1249-1253
[27]张新涛,江华基,梁祖儒,等.骨碎补总黄酮通过激活mTOR信号通路促进大鼠腱骨愈合的实验研究.中国骨伤,2018,31(3):248-253
[28]曾景奇.基于BMP-Smad通路探讨骨碎补总黄酮影响牵张成骨的初步研究.广州中医药大学博士论文,2016
[29]Lv J,Sun X,Ma J,et al.Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention ofneurectomy-induced bone loss by naringin.Biochem Biophys Res Commun,2015,468(4):587-593
[30]杨锋,孙玉华,吕中静,等.骨碎补总黄酮对骨质疏松症患者牙槽骨的影响.中国口腔颌面外科杂志,2018,16(1):34-40
[31]张春琪,刘鹏鹤.骨碎补总黄酮治疗绝经后女性骨质疏松症68例临床观察.中医临床研究,2015,7(28):103-104
[32]樊继波,覃勇,李莎,等.离子导入骨碎补总黄酮对骨质疏松症患者腰椎骨密度影响临床研究.中国骨质疏松杂志,2013,19(12):1256-1258
[33]丁小刚,覃勇,鄂建设,等.骨碎补总黄酮对老年性骨质疏松症患者血清骨钙素水平及骨密度影响.中国骨质疏松杂志,2013,19(5):519-521
[34]Zhang Y,Jiang J,Shen H,et al.Total flavonoids from Rhizoma Drynariae(Gusuibu)for treating osteoporotic fractures:implication in clinical practice.Drug Des Devel Ther,2017,11:1881-1890
[35]周瑞明,管义红,王全兵,等.强骨胶囊联合鹿瓜多肽注射液治疗老年原发性骨质疏松症的临床研究.现代药物与临床,2017,32(7):1337-1340
[36]韩亚力,罗奕,曾佳学.骨碎补总黄酮基于Notch信号通路改善骨质疏松的作用及机制研究.中国免疫学杂志,2018,34(2):261-266
[37]赖满香,廖利平,谭玮璐,等.“肾精-骨质疏松-骨髓间充质干细胞”理论探讨.中医杂志,2018,2(52):100-103
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