秀丽隐杆线虫Wnt途径异常对机械感知神经元的影响
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摘要
<正>Wnt蛋白是后生动物中一类保守的分泌配体糖蛋白.它们可以通过七跨膜卷曲蛋白受体(Frizzled)、酪氨酸激酶(Ryk和Ror)传递细胞内信号[1,2]. Wnt基因和Wnt信号通路的作用涉及广泛的生物学现象,其在生物个体的早期发育到细胞过程,影响疾病,尤其是癌症的发生、发展[3].在神经系统中, Wnt信号传导在神
引文
1 Prasad B C,Clark S G.Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C.elegans.Development,2006,133:1757-1766
2 Silhankova M,Korswagen H C.Migration of neuronal cells along the anterior-posterior body axis of C.elegans:Wnts are in control.Curr Opin Genets Dev,2007,17:320-325
3 Nusse R,Varmus H.Three decades of Wnts:A personal perspective on how a scientific field developed.EMBO J,2012,31:2670-2684
4 Durak O.Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders.Dissertation for Doctoral Degree.Massachusetts:Massachusetts Institute of Technology,2017.158-173
5 Endo M,Minami Y.Diverse roles for the ror-family receptor tyrosine kinases in neurons and glial cells during development and repair of the nervous system.Dev Dyn,2018,247:24-32
6 Clevers H,Nusse R.Wnt/β-catenin signaling and disease.Cell,2012,149:1192-1205
7 Pe?ina-Slaus N.Wnt signal transduction pathway and apoptosis:A review.Cancer Cell Int,2010,10:22
8 Pan C L,Howell J E,Clark S G,et al.Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans.Dev Cell,2006,10:367-377
9 Zinovyeva A Y,Forrester W C.The C.elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways.Dev Biol,2005,285:447-461
10 Inoue T,Oz H S,Wiland D,et al.C.elegans LIN-18 is a ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.Cell,2004,118:795-806
11 Saied-Santiago K,Townley R A,Attonito J D,et al.Coordination of heparan sulfate proteoglycans with Wnt signaling to control cellular migrations and positioning in Caenorhabditis elegans.Genetics,2017,206:1951-1967
12 Korswagen H C.Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans:Variations on a common signaling theme.Bioessays,2002,24:801-810
13 Herman M A.Control of cell polarity by noncanonical Wnt signaling in C.elegans.Semin Cell Dev Biol,2002,13:233-241
14 Kirszenblat L,Neumann B,Coakley S,et al.A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons.Mol Biol Cell,2013,24:285-296
15 Ma C,Zhang H T.Molecular mechanism of neuron polarization(in Chinese).Chem Life,2008,28:408-411[马超,张海涛.神经元极化的分子机制.生命的化学,2008,28:408-411]
16 Clark C E J,Liu Y,Cooper H M.The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration.Sci China Life Sci,2014,57:366-371
17 Su S,Wu W.Regulation of target gene transcription by Wnt/β-catenin signaling(in Chinese).Sci Sin Vitae,2014,44:1029-1042[苏尚,吴畏.Wnt/β-catenin信号通路对靶基因转录的调控.中国科学:生命科学,2014,44:1029-1042]
18 Hilliard M A,Bargmann C I.Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C.elegans.Dev Cell,2006,10:379-390
19 Fleming T,Chien S C,Vanderzalm P J,et al.The role of C.elegans Ena/VASP homolog UNC-34 in neuronal polarity and motility.Dev Biol,2010,344:94-106
20 Marín O,Valiente M,Ge X,et al.Guiding neuronal cell migrations.Cold Spring Harb Perspect Biol,2010,2:a001834
21 Boateng R,Nguyen K C Q,Hall D H,et al.Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses.Dev Biol,2017,429:306-320
22 Harterink M,Kim D H,Middelkoop T C,et al.Neuroblast migration along the anteroposterior axis of C.elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein.Development,2011,138:2915-2924
23 Wang X,Zhou F,Lv S,et al.Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.Proc Natl Acad Sci USA,2013,110:11175-11180
24 Kirszenblat L,Pattabiraman D,Hilliard M A.LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C.elegans neurons.PLoS Biol,2011,9:e1001157
25 White R R,Milholland B,MacRae S L,et al.Comprehensive transcriptional landscape of aging mouse liver.BMC Genomics,2015,16:899
26 Kulkarni G,Xu Z,Mohamed A M,et al.Experimental evidence for UNC-6(netrin)axon guidance by stochastic fluctuations of intracellular UNC-40(DCC)outgrowth activity.Biol Open,2013,2:1300-1312
27 Ahmad F J,Joshi H C,Centonze V E,et al.Inhibition of microtubule nucleation at the neuronal centrosome compromises axon growth.Neuron,1994,12:271-280
28 Chatzigeorgiou M,Schafer W R.Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C.elegans.Neuron,2011,70:299-309
29 Maguire S M,Clark C M,Nunnari J,et al.The C.elegans touch response facilitates escape from predacious fungi.Curr Biol,2011,21:1326-1330
30 Kass J,Jacob T C,Kim P,et al.The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.J Neurosci,2001,21:9265-9272
31 Kindt K S,Quast K B,Giles A C,et al.Dopamine mediates context-dependent modulation of sensory plasticity in C.elegans.Neuron,2007,55:662-676
32 Suzuki H,Kerr R,Bianchi L,et al.In vivo imaging of C.elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation.Neuron,2003,39:1005-1017
33 Rose J K,Rankin C H.Analyses of habituation in Caenorhabditis elegans.Learn Mem,2001,8:63-69
34 Sawin E R,Ranganathan R,Horvitz H R.C.elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.Neuron,2000,26:619-631
35 Chase D L,Koelle M R.Biogenic amine neurotransmitters in C.elegans.In:WormBook,ed.The C.elegans Research Community.Worm Book,2007.1-15
36 Hao Y,Yang W,Ren J,et al.Thioredoxin shapes the C.elegans sensory response to Pseudomonas produced nitric oxide.eLife,2018,7:e36833
37 Sanyal S,Wintle R F,Kindt K S,et al.Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.EMBO J,2004,23:473-482
38 Chang H C,Paek J,Kim D H.Natural polymorphisms in C.elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.Nature,2011,480:525-529
39 Ardiel E L,Rankin C H.An elegant mind:Learning and memory in Caenorhabditis elegans.Learn Mem,2010,17:191-201
40 Ezcurra M,Tanizawa Y,Swoboda P,et al.Food sensitizes C.elegans avoidance behaviours through acute dopamine signalling.EMBO J,2011,30:1110-1122
2 Silhankova M,Korswagen H C.Migration of neuronal cells along the anterior-posterior body axis of C.elegans:Wnts are in control.Curr Opin Genets Dev,2007,17:320-325
3 Nusse R,Varmus H.Three decades of Wnts:A personal perspective on how a scientific field developed.EMBO J,2012,31:2670-2684
4 Durak O.Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders.Dissertation for Doctoral Degree.Massachusetts:Massachusetts Institute of Technology,2017.158-173
5 Endo M,Minami Y.Diverse roles for the ror-family receptor tyrosine kinases in neurons and glial cells during development and repair of the nervous system.Dev Dyn,2018,247:24-32
6 Clevers H,Nusse R.Wnt/β-catenin signaling and disease.Cell,2012,149:1192-1205
7 Pe?ina-Slaus N.Wnt signal transduction pathway and apoptosis:A review.Cancer Cell Int,2010,10:22
8 Pan C L,Howell J E,Clark S G,et al.Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans.Dev Cell,2006,10:367-377
9 Zinovyeva A Y,Forrester W C.The C.elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways.Dev Biol,2005,285:447-461
10 Inoue T,Oz H S,Wiland D,et al.C.elegans LIN-18 is a ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.Cell,2004,118:795-806
11 Saied-Santiago K,Townley R A,Attonito J D,et al.Coordination of heparan sulfate proteoglycans with Wnt signaling to control cellular migrations and positioning in Caenorhabditis elegans.Genetics,2017,206:1951-1967
12 Korswagen H C.Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans:Variations on a common signaling theme.Bioessays,2002,24:801-810
13 Herman M A.Control of cell polarity by noncanonical Wnt signaling in C.elegans.Semin Cell Dev Biol,2002,13:233-241
14 Kirszenblat L,Neumann B,Coakley S,et al.A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons.Mol Biol Cell,2013,24:285-296
15 Ma C,Zhang H T.Molecular mechanism of neuron polarization(in Chinese).Chem Life,2008,28:408-411[马超,张海涛.神经元极化的分子机制.生命的化学,2008,28:408-411]
16 Clark C E J,Liu Y,Cooper H M.The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration.Sci China Life Sci,2014,57:366-371
17 Su S,Wu W.Regulation of target gene transcription by Wnt/β-catenin signaling(in Chinese).Sci Sin Vitae,2014,44:1029-1042[苏尚,吴畏.Wnt/β-catenin信号通路对靶基因转录的调控.中国科学:生命科学,2014,44:1029-1042]
18 Hilliard M A,Bargmann C I.Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C.elegans.Dev Cell,2006,10:379-390
19 Fleming T,Chien S C,Vanderzalm P J,et al.The role of C.elegans Ena/VASP homolog UNC-34 in neuronal polarity and motility.Dev Biol,2010,344:94-106
20 Marín O,Valiente M,Ge X,et al.Guiding neuronal cell migrations.Cold Spring Harb Perspect Biol,2010,2:a001834
21 Boateng R,Nguyen K C Q,Hall D H,et al.Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses.Dev Biol,2017,429:306-320
22 Harterink M,Kim D H,Middelkoop T C,et al.Neuroblast migration along the anteroposterior axis of C.elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein.Development,2011,138:2915-2924
23 Wang X,Zhou F,Lv S,et al.Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.Proc Natl Acad Sci USA,2013,110:11175-11180
24 Kirszenblat L,Pattabiraman D,Hilliard M A.LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C.elegans neurons.PLoS Biol,2011,9:e1001157
25 White R R,Milholland B,MacRae S L,et al.Comprehensive transcriptional landscape of aging mouse liver.BMC Genomics,2015,16:899
26 Kulkarni G,Xu Z,Mohamed A M,et al.Experimental evidence for UNC-6(netrin)axon guidance by stochastic fluctuations of intracellular UNC-40(DCC)outgrowth activity.Biol Open,2013,2:1300-1312
27 Ahmad F J,Joshi H C,Centonze V E,et al.Inhibition of microtubule nucleation at the neuronal centrosome compromises axon growth.Neuron,1994,12:271-280
28 Chatzigeorgiou M,Schafer W R.Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C.elegans.Neuron,2011,70:299-309
29 Maguire S M,Clark C M,Nunnari J,et al.The C.elegans touch response facilitates escape from predacious fungi.Curr Biol,2011,21:1326-1330
30 Kass J,Jacob T C,Kim P,et al.The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.J Neurosci,2001,21:9265-9272
31 Kindt K S,Quast K B,Giles A C,et al.Dopamine mediates context-dependent modulation of sensory plasticity in C.elegans.Neuron,2007,55:662-676
32 Suzuki H,Kerr R,Bianchi L,et al.In vivo imaging of C.elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation.Neuron,2003,39:1005-1017
33 Rose J K,Rankin C H.Analyses of habituation in Caenorhabditis elegans.Learn Mem,2001,8:63-69
34 Sawin E R,Ranganathan R,Horvitz H R.C.elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.Neuron,2000,26:619-631
35 Chase D L,Koelle M R.Biogenic amine neurotransmitters in C.elegans.In:WormBook,ed.The C.elegans Research Community.Worm Book,2007.1-15
36 Hao Y,Yang W,Ren J,et al.Thioredoxin shapes the C.elegans sensory response to Pseudomonas produced nitric oxide.eLife,2018,7:e36833
37 Sanyal S,Wintle R F,Kindt K S,et al.Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.EMBO J,2004,23:473-482
38 Chang H C,Paek J,Kim D H.Natural polymorphisms in C.elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.Nature,2011,480:525-529
39 Ardiel E L,Rankin C H.An elegant mind:Learning and memory in Caenorhabditis elegans.Learn Mem,2010,17:191-201
40 Ezcurra M,Tanizawa Y,Swoboda P,et al.Food sensitizes C.elegans avoidance behaviours through acute dopamine signalling.EMBO J,2011,30:1110-1122