A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control 一项评估联合使用磺脲与二甲双胍治疗后血糖仍然控制不佳的2型糖尿病患者加用西格列汀治疗后的安全性与有效性的随机临床试验

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• 作者：Robert G. Moses ; Elizabeth Round ; Yue Shentu ; Gregory T. Golm ; Edward A. O' ; neill ; Ira Gantz ; Samuel S. Engel ; Keith D. Kaufman and Barry J. Goldstein
• 刊名：Journal of Diabetes
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：8
• 期：5
• 页码：701-711
• 全文大小：788K
• ISSN：1753-0407

文摘

Type 2 diabetes mellitus (T2DM) treatment generally requires multiple antihyperglycemic agents. When diet, exercise, and treatment with sulfonylurea and metformin do not achieve glycemic goals, several options are available. The present study evaluated the efficacy and tolerability of sitagliptin 100 mg/day added to therapy with sulfonylurea and metformin.