Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia
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- 作者：Franziska Richter ; DVM ; PhDa ; 1 ; franziska.richter@vmf.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Julia Gerstenberger ; DVMa ; 1 ; julia.gerstenberger@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Anne Bauer ; DVMa ; anne.bauer@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Chun-Chi Liang ; PhDb ; chunchi@med.umich.edu" class="auth_mail" title="E-mail the corresponding author ; Angelika Richter ; DVM ; PhDa ; angelika.richter@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：DYT1 KI ; knock in mouse model of DYT1 dystonia ; ARB ; adaptive rotating beam
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：536-541
- 全文大小：1126 K
文摘
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We established a behavioural readout for neuronal dysfunction in DYT1 KI mice.
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DYT1 KI mice exhibited sensorimotor deficits in the adhesive removal test.
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Deficits were detected in a complex rotating beam test with changing sensory input.
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Deficits may reflect previously shown cerebellothalamocortical tract alterations.
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