Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials

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• 作者：Giuseppe Derosa^a ; ^b ; ^c ; ^d ; Pamela Maffioli^a ; ^e ; Luis E. Simental-Mendí ; a^f ; Simona Bo^g ; Amirhossein Sahebkar^h ; ^{sahebkara@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{amir_saheb2000@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Curcuma longa ; Curcumin ; Inflammation ; Meta-analysis ; Interleukin-6
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：394-404
• 全文大小：2397 K

文摘

The aim of this meta-analysis was to evaluate the efficacy of curcuminoids supplementation on circulating concentrations of IL-6 in randomized controlled trials (RCTs).

The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to November 01, 2015, to identify RCTs investigating the impact of curcuminoids on circulating IL-6 concentrations.

Nine RCTs comprising 10 treatment arms were found to be eligible for the meta-analysis. There was a significant reduction of circulating IL-6 concentrations following curcuminoids supplementation (WMD: −0.60 pg/mL, 95% CI: −1.06, −0.14, p = 0.011). Meta-regression did not suggest any significant association between the circulating IL-6 lowering effects of curcuminoids with either dose or duration of treatment. There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: −0.51; 95% CI: −0.80, −0.23; p = 0.005).

This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations. This effect appears to be more evident in patients with higher degrees of systemic inflammation.