Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
详细信息 查看全文
- 作者：Masaya Yamaguchi1 ; 6 ; Ryan VanderLinden1 ; 2 ; 6 ; Florian Weissmann3 ; 6 ; Renping Qiao3 ; Prakash Dube4 ; Nicholas G. Brown1 ; David Haselbach4 ; Wei Zhang5 ; Sachdev S. Sidhu5 ; Jan-Michael Peters3 ; jan-michael.peters@imp.ac.at" class="auth_mail" title="E-mail the corresponding author ; Holger Stark4 ; hstark1@gwdg.de" class="auth_mail" title="E-mail the corresponding author ; Brenda A. Schulman1 ; 2 ; brenda.schulman@stjude.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：18 August 2016
- 年：2016
- 卷：63
- 期：4
- 页码：593-607
- 全文大小：6694 K
文摘
- •
Cryo-EM shows reciprocal and conformational regulation of APC/CCDC20 and MCC
- •
MCC blocks APC/CCDC20-binding sites for substrates such as Cyclins and Securin
- •
Closed APC/CCDC20-MCC blocks E2 UBE2C, as during the spindle checkpoint
- •
Open APC/CCDC20-MCC directs ubiquitination of MCC, as during checkpoint silencing
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |