Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
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- 作者：Nicholas G. Brown1 ; 9 ; Ryan VanderLinden1 ; 2 ; 9 ; Edmond R. Watson1 ; 9 ; Florian Weissmann3 ; Alban Ordureau4 ; Kuen-Phon Wu1 ; Wei Zhang5 ; Shanshan Yu1 ; Peter Y. Mercredi1 ; Joseph S. Harrison6 ; Iain F. Davidson3 ; Renping Qiao3 ; Ying Lu7 ; Prakash Dube8 ; Michael R. Brunner1 ; Christy R.R. Grace1 ; Darcie J. Miller1 ; David Haselbach8 ; Marc A. Jarvis3 ; Masaya Yamaguchi1 ; David Yanishevski1 ; Georg Petzold3 ; Sachdev S. Sidhu5 ; Brian Kuhlman6 ; Marc W. Kirschner7 ; J. Wade Harper4 ; Jan-Michael Peters3 ; jan-michael.peters@imp.ac.at" class="auth_mail" title="E-mail the corresponding author ; Holger Stark8 ; hstark1@gwdg.de" class="auth_mail" title="E-mail the corresponding author ; Brenda A. Schulman1 ; 2 ; brenda.schulman@stjude.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：165
- 期：6
- 页码：1440-1453
- 全文大小：4292 K
文摘
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Cryo-EM shows mechanisms of polyubiquitination by cell-cycle regulator APC/C
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Distinct cullin-RING-E2 architectures for multiubiquitination and chain elongation
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RING activates UBE2C and binds substrate-linked ubiquitin to amplify processivity
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RING delivers ubiquitin for K11-linked chain elongation by UBE2S placed by cullin
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