Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

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• 作者：Hamed Mirzaei^a ; Abolfazl Shakeri^b ; Bahman Rashidi^e ; Amin Jalili^a ; Zarrin Banikazemi^c ; Amirhossein Sahebkar^d ; ^{amir_saheb2000@yahoo.com} ; ^{sahebkara@mums.ac.ir}
• 关键词：Curcumin ; Phospholipid ; Bioavailability ; Phytosome
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：102-112
• 全文大小：1247 K
• 卷排序：85

文摘

Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8 g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability. Existence of phospholipids in phytosomes leads to specific physicochemical properties such as amphiphilic nature that allows dispersion in both hydrophilic and lipophilic media. The efficacy and safety of curcumin phytosomes have been shown against several human diseases including cancer, osteoarthritis, diabetic microangiopathy and retinopathy, and inflammatory diseases. This review focuses on the pharmacokinetics as well as pharmacological and clinical effects of phytosomal curcumin.