Stereospecific and Stereoselective Alkyl and Silylcyclopropanation of ,mg src="http://pubs.acs.org/images/gifchars/beta2.gif" bord

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• 作者：José ; M. Concell&oacute ; n ; Humberto Rodrí ; guez-Solla ; Carmen Mé ; jica ; Elena G. Blanco ; Santiago Garcí ; a-Granda ; M. Rosario Dí ; az
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：January 17, 2008
• 年：2008
• 卷：10
• 期：2
• 页码：349 - 352
• 全文大小：63K
• 年卷期：v.10,no.2(January 17, 2008)
• ISSN：1523-7052

文摘

LE>l702876rn00002>MG SRC="/isubscribe/journals/orlef7/10/i02/figures/ol702876rn00002.gif" ALIGN="left" HSPACE=5>A novel chromium-promoted alkyl- and silyl cyclopropanation of (E)- or (Z)-mages/gifchars/alpha.gif" BORDER=0>,mages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-unsaturated amides in which the C-C double bond is di-, ortrisubstituted is described. This process takes place with total stereospecificity, and the new stereogenic center is generated with high or totalstereoselectivity. A mechanism is proposed to explain the cyclopropanation reaction.