Human Metabolic Phenotypes Link Directly to Specific Dietary Preferences in Healthy Individuals

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• 作者：Serge Rezzi ; Ziad Ramadan ; Franç ; ois-Pierre J. Martin ; Laurent B. Fay ; Peter van Bladeren ; John C. Lindon ; Jeremy K. Nicholson ; Sunil Kochhar
• 刊名：Journal of Proteome Research
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：6
• 期：11
• 页码：4469 - 4477
• 全文大小：390K
• 年卷期：v.6,no.11(November 2007)
• ISSN：1535-3907

文摘

Individual human health is determined by a complex interplay between genes, environment, diet,lifestyle, and symbiotic gut microbial activity. Here, we demonstrate a new "nutrimetabonomic"approach in which spectroscopically generated metabolic phenotypes are correlated with behavioral/psychological dietary preference, namely, "chocolate desiring" or "chocolate indifferent". Urinary andplasma metabolic phenotypes are characterized by differential metabolic biomarkers, measured using¹H NMR spectroscopy, including the postprandial lipoprotein profile and gut microbial co-metabolism.These data suggest that specific dietary preferences can influence basal metabolic state and gutmicrobiome activity that in turn may have long-term health consequences to the host. Nutrimetabonomics appears as a promising approach for the classification of dietary responses in populations andpersonalized nutritional management.