Tungsten-Mediated Selective Ring Opening of Vinylcyclopropanes

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• 作者：Jared A. Pienkos ; Anne T. Knisely ; Benjamin K. Liebov ; Victor Teran ; Victor E. Zottig ; Michal Sabat ; William H. Myers ; W. Dean Harman
• 刊名：Organometallics
• 出版年：2014
• 出版时间：January 13, 2014
• 年：2014
• 卷：33
• 期：1
• 页码：267-277
• 全文大小：472K
• ISSN：1520-6041

文摘

The complexes TpW(NO)(PMe₃)(L), where L = 2H-phenol, 2H-p-cresol, 2H-5,6,7,8-tetrahydro-2-naphthol, 2H-N,N-dimethylanilinium were cyclopropanated using Simmons鈥揝mith conditions. Cyclopropanated derivatives of 2H-N,N-dimethylanilinium were selectively ring-opened with HOTf/MeCN to form allylic species, which could be coupled with various nucleophiles. The nucleophilic addition occurs anti to the metal fragment, as determined by X-ray crystallography. Moreover, the cyclopropane ring opening occurs regioselectively, owing to the stabilization of the allylic cation by the metal fragment. The resulting ligands can, in some cases, be removed from the metal by oxidative decomplexation using ceric ammonium nitrate (CAN).