Cascade Reaction of Isatins with Heterocyclic Ketene Aminals: Synthesis of Imidazopyrroloquinoline Derivatives

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• 作者：Fuchao Yu ; Shengjiao Yan ; Ling Hu ; Yongchao Wang ; Jun Lin
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：September 16, 2011
• 年：2011
• 卷：13
• 期：18
• 页码：4782-4785
• 全文大小：819K
• 年卷期：v.13,no.18(September 16, 2011)
• ISSN：1523-7052

文摘

A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol.