Copper-Catalyzed Oxidative Cyclization of 1,5-Enynes with Concomitant C鈥揅 Bond Cleavage: An Unexpected Access to 3-Formyl-1-indenone Derivatives

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• 作者：Jian Zhang ; Degui Wu ; Xiaoling Chen ; Yunkui Liu ; Zhenyuan Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：79
• 期：11
• 页码：4799-4808
• 全文大小：621K
• 年卷期：v.79,no.11(June 6, 2014)
• ISSN：1520-6904

文摘

A Cu(0)/Selectfluor system-mediated oxidative cyclization of 1,5-enynes with concomitant C鈥揅 bond cleavage to access 3-formyl-1-indenone derivatives is described. Preliminary mechanistic investigations disclosed that the C鈥揅 bond cleavage involved a novel water-participated oxygen-insertion 尾-carbon elimination through double oxycuprations.