A dynamic reaction cell (DRC) has been used to minimizethe formation of metal-argide ions in inductively coupledplasma mass spectrometry and applied to the determination of Zr and Nb in Cr-rich samples. The formation ofArCr+ species from the plasma gas and the sample matrixwas reduced by ion molecule reactions inside a DRC ofthe ICPMS used. Hydrogen was used as reaction gas, andthe efficiency in the reduction of ArCr+ was similar to thatof other plasma-based polyatomic ions as reported in anearlier study. The formation of CrOx+ ions is enhancedwhen the DRC is operated in pressurized mode. Adjustment of the transmission properties of the band-passquadrupole to reject precursor ions can be achievedwithout dramatic decrease of sensitivity but with a significant improvement in the signal/background ratio.Measurements in solutions containing concentrations ofup to 2 g/L Cr showed that the determination of Nb andZr is possible in the nanogram per liter range in such amatrix. The limits of detection for Nb and Zr in pure Crmetal have been estimated at 2 ng/g for Nb and 5 ng/gfor Zr. Analysis of basaltic reference samples resulted invery good agreement with previously published data.