Neuroprotective Effects of Longan (Dimocarpus longan Lour.) Flower Water Extract on MPP+-Induced Neurotoxicity in Rat Brain

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• 作者：Anya Maan-Yuh Lin ; Liang-Yi Wu ; Kai-Chih Hung ; Hui-Ju Huang ; Yen Ping Lei ; Wen-Chien Lu ; Lucy Sun Hwang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2012
• 出版时间：September 12, 2012
• 年：2012
• 卷：60
• 期：36
• 页码：9188-9194
• 全文大小：343K
• 年卷期：v.60,no.36(September 12, 2012)
• ISSN：1520-5118

文摘

In this study, the neuroprotective effect of Dimocarpus longan Lour. flower water extract (LFWE) was investigated. First, an in vitro study showed that LFWE concentration-dependently inhibited lipid peroxidation of brain homogenates incubated at 37 掳C. The antioxidative activity of LFWE was more potent than that of glutathione or Trolox. Furthermore, an ex vivo study found that the basal lipid peroxidation (0 掳C) and lipid peroxidation incubated at 37 掳C were lower in the brain homogenates of LFWE-treated (500 mg/day) rats, indicating that the brain of LFWE-treated rats was more resistant to oxidative stress. Moreover, a Parkinsonian animal model was employed to demonstrate that oral administration of LFWE (125鈥?00 mg/kg/day) dose-dependently attenuated 1-methyl-4-phenylpyridinium (MPP⁺)-induced neurotoxicity in the nigrostriatal dopaminergic system of rat brain. In conclusion, this study suggests that LFWE is antioxidative, anti-inflammatory, and anti-apoptotic. Furthermore, oral administration of LFWE appears to be useful in preventing and/or treating central nervous system neurodegenerative diseases, including Parkinsonism.

Keywords:

Dimocarpus longan Lour.; MPP⁺; neurotoxicity; oxidative stress; 伪-synuclein aggregation; anti-inflammation; anti-apoptosis