Growth Inhibition of Human Colon Carcinoma Cells by Sesquiterpenoids and Tetralones of Zygogynum calothyrsum

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• 作者：Krishna P. Devkota ; David Covell ; Tanya Ransom ; James B. McMahon ; John A. Beutler
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：710-714
• 全文大小：242K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Bioassay-guided phytochemical investigation of Zygogynum calothyrsum using the human colon carcinoma cell lines COLO205 and KM12 led to the isolation of three new drimane-type sesquiterpenoids, 1尾-p-hydroxy-E-cinnamoyldrimeninol (1), 1尾-p-hydroxy-E-cinnamoyl-5伪-hydroxydrimeninol (2), and methyl ether of 1尾-p-hydroxy-E-cinnamoyl-12伪-methoxydrimeninol (3). Also isolated was the known 1尾-p-coumaroyloxypolygodial (4) together with two new tetralones, 3鈥?deoxyisozygolone A (5) and calothyrlone A (9), three known tetralones, isozygolone A (6), zygolone A (7), and 4鈥?O-methylzygolone A (8), and a known cinnamolide (10). Compounds 1, 7, and 8 demonstrated higher cytotoxicity against COLO205 (GI₅₀ 18, 17, and 11 渭M, respectively) and KM12 (GI₅₀ 14, 14, and 17 渭M, respectively) than the other compounds.