Aogacillins A and B Produced by Simplicillium sp. FKI-5985: New Circumventors of Arbekacin Resistance in MRSA

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• 作者：Keiko Takata ; Masato Iwatsuki ; Tsuyoshi Yamamoto ; Tatsuya Shirahata ; Kenichi Nonaka ; Rokuro Masuma ; Yoichi Hayakawa ; Hideaki Hanaki ; Yoshinori Kobayashi ; George A. Petersson ; Satoshi O虆mura ; Kazuro Shiomi
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 20, 2013
• 年：2013
• 卷：15
• 期：18
• 页码：4678-4681
• 全文大小：268K
• 年卷期：v.15,no.18(September 20, 2013)
• ISSN：1523-7052

文摘

Aogacillins A and B, capable of overcoming arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA), were isolated from a culture broth of Simplicillium sp. FKI-5985. Their structures were elucidated by NMR spectroscopic studies and ECD analyses. The aogacillins possessed a novel carbon skeleton, including a 尾-keto-纬-methyliden-未-lactone ring connected to a 2-ethyl-6-methylcyclohexane ring by spiro conjugation.