Photostability of Hydroxocobalamin: Ultrafast Excited State Dynamics and Computational Studies
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- 作者：Theodore E. Wiley ; William R. Miller ; Nicholas A. Miller ; Roseanne J. Sension ; Piotr Lodowski ; Maria Jaworska ; Pawel M. Kozlowski
- 刊名：The Journal of Physical Chemistry Letters
- 出版年：2016
- 出版时间：January 7, 2016
- 年：2016
- 卷：7
- 期：1
- 页码：143-147
- 全文大小：378K
- ISSN：1948-7185
文摘
Hydroxocobalamin is a potential biocompatible source of photogenerated hydroxyl radicals localized in time and space. The photogeneration of hydroxyl radicals is studied using time-resolved spectroscopy and theoretical simulations. Radicals are only generated for wavelengths <350 nm through a mechanism that involves competition between prompt dissociation and internal conversion. Characterization of the lowest-lying singlet potential energy surface provides insight into the photochemistry of hydroxocobalamin and other cobalamin compounds.