Tritylium Cation as Low Loading Lewis Acidic Organocatalyst in Povarov Reactions

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• 作者：Yu Huang ; Chuanhong Qiu ; Zhenjiang Li ; Weiyang Feng ; Haifeng Gan ; Jingjing Liu ; Kai Guo
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：4
• 期：1
• 页码：47-52
• 全文大小：420K
• ISSN：2168-0485

文摘

Triphenylmethylium cation catalyzed Povarov reactions with excellent yields in 1 h with a remarkably low loading (0.5 mol %) are disclosed. A Lewis acidic carbenium catalysis mechanism was proposed and validated. A three-component Povarov reaction in a batch was transferred into a two-stage microflow process, which resulted in a 60-fold reduction in reaction time from 2 h to 2 min with 89% separated yield.