Tin Tungstate Nanoparticles: A Photosensitizer for Photodynamic Tumor Therapy

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• 作者：Carmen Seidl ; Jan Ungelenk ; Eva Zittel ; Thomas Bergfeldt ; Jonathan P. Sleeman ; Ute Schepers ; Claus Feldmann
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：March 22, 2016
• 年：2016
• 卷：10
• 期：3
• 页码：3149-3157
• 全文大小：498K
• ISSN：1936-086X

文摘

The nanoparticulate inorganic photosensitizer β-SnWO₄ is suggested for photodynamic therapy (PDT) of near-surface tumors via reiterated 5 min blue-light LED illumination. β-SnWO₄ nanoparticles are obtained via water-based synthesis and comprise excellent colloidal stability under physiological conditions and high biocompatibility at low material complexity. Antitumor and antimetastatic effects were investigated with a spontaneously metastasizing (4T1 cells) orthotopic breast cancer BALB/c mouse model. Besides protamine-functionalized β-SnWO₄ (23 mg/kg of body weight, in PBS buffer), chemotherapeutic doxorubicin was used as positive control (2.5 mg/kg of body weight, in PBS buffer) and physiological saline (DPBS) as a negative control. After 21 days, treatment with β-SnWO₄ resulted in a clearly inhibited growth of the primary tumor (all tumor volumes below 3 cm³) as compared to the doxorubicin and DPBS control groups (volumes up to 6 cm³). Histological evaluations of lymph nodes and lungs as well as the volume of ipsilateral lymph nodes show a remarkable antimetastatic effect being similar to chemotherapeutic doxorubicin but—according to blood counts—at significantly reduced side effects. On the basis of low material complexity, high cytotoxicity under blue-light LED illumination at low dark and long-term toxicity, β-SnWO₄ can be an interesting addition to PDT and the treatment of near-surface tumors, including skin cancer, esophageal/gastric/colon tumors as well as certain types of breast cancer.