Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications

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• 作者：Johan R. Johansson ; Tamás Beke-Somfai ; Anna Said Stålsmeden ; Nina Kann
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：December 14, 2016
• 年：2016
• 卷：116
• 期：23
• 页码：14726-14768
• 全文大小：2500K
• ISSN：1520-6890

文摘

The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer. The RuAAC reaction has quickly found its way into the organic chemistry toolbox and found applications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis, supramolecular chemistry, and the construction of electronic devices. This Review discusses the mechanism, scope, and applications of the RuAAC reaction, covering the literature from the last 10 years.