Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals

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• 作者：Zhe ZhouZhiwei Ma ; Nicole Erin Behnke ; Hongyin Gao ; László Kürti
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：139
• 期：1
• 页码：115-118
• 全文大小：386K
• ISSN：1520-5126

文摘

Herein we disclose a novel method for the facile transfer of primary (−NH₂) and secondary amino groups (−NHR) to heteroaryl- as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing groups. This one-pot transformation allows unprecedented functional group tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper(I) salt is required.