Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat

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• 作者：Denk ; Gerald U. ; Soroka ; Carol J. ; Takeyama ; Yasuaki ; Chen ; Wen-Sheng ; Schuetz ; John D. ; Boyer ; James L.
• 关键词：ATP-binding cassette transporter ; Bile acids ; Bile duct ligation ; Cyclic adenosine monophosphate ; Cyclic nucleotides ; Multidrug resistance-associated protein 4
• 刊名：Journal of Hepatology
• 出版年：2004
• 期刊代码：162_01688278
• 类别：med
• 出版时间：April, 2004
• 卷：40
• 期：4
• 页码：585-591
• 文件大小：718 K

摘要

Multidrug resistance-associated protein 4 (Mrp4, ABCC4) transports cyclic nucleotides, anti-retroviral compounds, and sulfated bile acids. Mrp4 expression is increased in farnesyl/bile acid receptor knockout mice. Our aim was to investigate Mrp4 expression and function in rat liver and kidney in obstructive cholestasis.