Cytokine Gene Polymorphisms Are Not Associated With Bronchiolitis Obliterans Syndrome or Survival After Lung Transplant

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• 作者：Laurie D. Snyder ; Matthew G. Hartwig ; Tonya Ganous ; R. Duane Davis ; Walter F. Herczyk ; Nancy L. Reinsmoen ; David A. Schwartz ; Scott M. Palmer
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：2006
• 期刊代码：161_10532498
• 类别：med
• 出版时间：November 2006
• 卷：25
• 期：11
• 页码：1330-1335
• 文件大小：334 K

摘要

Background

Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort.

Methods

All patients who underwent lung transplantation from 1993 to 1998 and had post-transplant survival of at least 6 months were included in the initial analysis. Subjects were genotyped for: TNF-α −308 G/A; IFN-γ +874 A/T; TGF-β1 +869 T/C and +915 G/C; IL-10 −1082 A/G, −819 C/T and −592 C/A; and IL-6 −174 G/C. End-points were onset of broncholitis obliterans syndrome (BOS) and survival.

Results

In the cohort, 78 subjects, with an overall mean ± SE survival 2,339 ± 117 days, had no correlation between onset of BOS1, BOS2 or survival with TNF-α, IFN-γ, TGF-β1 or IL-10 gene polymorphisms. However, IL-6 polymorphisms GG or GC were associated with an earlier onset of BOS1 (p = 0.039), BOS2 (p = 0.021), and decreased overall post-transplant survival (p = 0.038). A second cohort of more recent lung transplant recipients did not validate an association between IL-6 polymorphisms and earlier onset of BOS1 (p = 0.70), BOS2 (p = 0.54) or overall post-transplant survival (p = 0.25).

Conclusions

Polymorphisms of TNF-α, IFN-γ, TGF-β1, IL-10 and IL-6 do not appear to influence the onset of BOS or graft survival in recipients.