Blends of TiO₂ nanoparticles and poly (N-isopropylacrylamide)-co-polystyrene nanofibers as a means to promote the biorecognition of an anticancer drug

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• 作者：Min Song ; Chao Pan ; Jingyuan Li ; Renyun Zhang ; Xuemei Wang ; Zhongze Gu
• 关键词：Biomaterials ; Thin films ; Electrochemistry ; Self-organization ; Polymer ; Anticancer drug
• 刊名：Talanta
• 出版年：2008
• 期刊代码：106_00399140
• 类别：ch
• 出版时间：30 May 2008
• 卷：75
• 期：4
• 页码：1035-1040
• 文件大小：610 K

摘要

The poly (N-isopropylacrylamide)-co-polystyrene (PNIPAM-co-PS) nanofibers have been fabricated by electrospinning, and the blends of PNIPAM-co-PS nanofibers with titanium dioxide (TiO₂) nanoparticles have been characterized and utilized as the new nanocomposites to enhance the relevant detection sensitivity of biomolecular recognition of an anticancer drug daunorubicin. Our observations demonstrate that upon application of the nanoTiO₂–PNIPAM-co-PS polymer nanocomposites, the drug molecules could be readily deposited on the surface of the relevant blends so that the remarkable enhancement effect of the new nanocomposites on the respective biorecognition of daunorubicin could be observed, suggesting the potential valuable application of the blending of the nanoTiO₂ and PNIPAM-co-PS polymer nanocomposites in high sensitive bioanalysis.