Copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole: synthesis, characterization, antiproliferative and antibacterial studies. Crystal struc

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• 作者：Chaviara ; A.Th. ; Cox ; P.J. ; Repana ; K.H. ; Papi ; R.M. ; Papazisis ; K.T. ; Zambouli ; D. ; Kortsaris ; A.H. ; et. al.
• 关键词：Schiff bases ; Copper(II) compounds ; Dien ; X-ray study ; Antiproliferative&ndash ; antibacterial studies ; Thiazoles
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2004
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：August, 2004
• 卷：98
• 期：8
• 页码：1271-1283
• 文件大小：506 K

摘要

A new series of coordination compounds of the starting materials [Cu(dienX₂Y₂)] and their adducts [Cu(dienXXY₂)(2a-5mt)] (where dien=diethylenetriamine, dienXX=Schiff bases of diethylenetriamine with 2-furaldehyde or 2-thiophene-carboxaldehyde, X=O, S, Y=Cl, Br, NO₃ and 2a-5mt=2-amino-5-methylthiazole) were synthesized by stepwise reactions and their structures were established by C, H, N, Cu analysis, spectroscopic, magnetic and molar conductivity measurements. The isolated compounds are monomers, paramagnetic and electrolytic compounds of the type 1:1. In all cases, the pentadentate Schiff base (dienXX) is bonded in a tridentate fashion through the 3 N atoms. In the CudienXXY₂ compounds the coordination sphere is completed by two Cl or Br or NO₃ groups in a square pyramidal arrangement. The proposed structure for this type of compound was further supported by X-ray diffraction analysis of the compound [Cu(dienOO)Cl₂]. Its basal plane consists of three Cu–N contacts [2.017(2), 2.025(2) and 2.012(2) Å] from dienOO, and the Cl(1) atom, while the Cl(2) atom possesses the apical position, the relevant distances being 2.2732(7) Å for Cu–Cl(1) and 2.6051(7) Å Cu–Cl(2). In the CudienX₂Y₂·2a-5mt adducts the coordination sphere of copper is further completed by the nitrogen ring atom of the 2a-5mt, forming an octahedral configuration. The study of the biological activity of the compounds synthesized against a panel of different normal and cancer cell lines (MRC5, HeLa, MCF7, HT-29, OAW42, T47D) and bacteria (E. coli, B. cereus, B. subtilis) showed that the adducts of the type [Cu(dienXXY₂)(2a-5mt)] exhibit increased activity both in cancer cells and in bacteria, compared to the starting material of type [Cu(dienXXY₂)].