• 作者：J. Candell-Riera^a ; ^{jcandell@vhebron.net} ; G. Romero-Farina^a ; S. Aguadé ; -Bruix^b ; J. Castell-Conesa^b ; V. Aliaga^a ; G. Cuberas-Borró ; s^a ; D. Garcí ; a-Dorado^a
• 关键词：Fracci&oacute ; n de eyecci&oacute ; n ; Gated-SPECT ; Miocardiopatí ; a isqué ; mica
• 刊名：Revista Espa帽ola de Medicina Nuclear
• 出版年：2010
• 期刊代码：pca315_02126982
• 类别：med
• 出版时间：July-August 2010
• 卷：29
• 期：4
• 页码：151-156
• 文件大小：325 K

Objective

The purpose of this study was to analyze left systolic ventricular function and myocardial perfusion characteristics between short one day exercise-rest and long two days gated SPECT (Single Photon Emission Computed Tomography) protocols in patients with ischemic cardiomyopathy (ICM).

Methods

A prospective study of 40 patients (59.6卤8.9 years, 3 women) with IHD (left ventricular ejection fraction (EF) 鈮?0%) was performed with myocardial perfusion gated SPECT. From 5 to 10 days after a one-day exercise-rest study (gated SPECT-1), patients were called back for a second rest study (gated SPECT-2) in order to compare EF and differences in perfusion summed rest score (螖SRS=SRS1鈥揝RS2) and summed difference score (螖SDS=SDS1鈥揝DS2) between both protocols.

Results

Between rest-gated SPECT-1 (short protocol) and rest-gated SPECT-2 (long protocol) EF increased (34%vs 37%, P= 0.008) in 26 patients (65%), and in 11 patients (27.5%) the increase was 鈮?%. There were no significant differences in clinical and coronary angiography variables between patients with and without increase of the EF 鈮?%. In the multivariate analysis, 螖SRS (95%CI: 鈭?.1 to 鈭?9.2) and 螖SDS (0.179鈥?.236) were predictors for this EF increase between both studies.

Conclusions

Exercise-rest short protocol can underestimate EF in patients with CM. Stunning but also contamination of rest images by previous exercise images in a short protocol could explain these results.