• 作者：Carolina Diez Morrondo ; ^{caroldiez81@hotmail.com} ; José ; Manuel Lema Gontad ; Noelia Á ; lvarez Rivas ; Antonio Atanes Sandoval ; Francisco Javier De Toro Santos ; José ; Antonio Pinto Tasende ; Fausto Galdo
• 关键词：Sí ; ndrome seco ; Sí ; ndrome de Sj&ouml ; gren ; Tumefacció ; n parotí ; dea
• 刊名：Seminarios de la Fundaci贸n Espa帽ola de Reumatolog铆a
• 出版年：2010
• 期刊代码：pca343_15773566
• 类别：med
• 出版时间：April-June 2010
• 卷：11
• 期：2
• 页码：70-76
• 文件大小：214 K

Sj枚gren's Syndrome (SS) is a chronic autoimmune disorder of the exbaocrine glands with associated lymphocytic infiltrates of the affected glands. SS occurs in a primary form not associated with other diseases and in a secondary form that complicates other rheumatic conditions. In both primary and secondary SS, decreased exocrine gland function leads to the 鈥渟icca complex鈥? a combination of dry eyes (xerophthalmia) and dry mouth (xerostomia). The clinical manifestations also include extraglandular disease features (skin, joints and muscles, lungs, kidneys, gastrointestinal tract). A variety of classification schemes have been proposed and discussed in the literature since the 1980s. The latest criteria, known as the American-European classification criteria for SS, were proposed in 2002. These criteria suggest that diagnosis of primary SS requires 4 of 6 criteria, including a positive minor-salivary biopsy sample and/or SS-A/SS-B antibodies. Therapy can be grouped into two separate aspects: treatment of dry eyes and dry mouth (replacement tears, muscarinic agonist agents鈥? and treatment of extraglandular manifestations (steroidal and non-steroidal anti-inflammatory agents, disease modifying agents, cytotoxic agents and biological therapies).