cAMP: Novel concepts in compartmentalised signalling

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• 作者：Helen V. Edwards ; Frank Christian ; George S. Baillie ; ^{George.Baillie@glasgow.ac.uk}
• 关键词：cAMP ; cyclic adenosine 3&prime ; 5&prime ; -monophosphate ; GPCR ; G protein-coupled receptor ; EC coupling ; excitation&ndash ; contraction coupling ; FRET ; Fö ; rster/fluorescence resonance energy transfer ; CFP ; cyan fluorescent protein ; YFP ; yellow fluorescent
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2012
• 期刊代码：186_10849521
• 类别：bio
• 出版时间：April, 2012
• 卷：23
• 期：2
• 页码：181-190
• 文件大小：690 K

摘要

Cyclic adenosine 3,鈥?鈥?monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 1980s. Since then, modern molecular techniques have facilitated visualisation of cellular cAMP dynamics in real time and helped us to understand how a single, ubiquitous second messenger can direct receptor-specific functions in cells. The aim of this review is to highlight emerging ideas in the cAMP field that are currently developing the concept of compartmentalised cAMP signalling systems.