The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis

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• 作者：Ljiljana Stojkovi&#263 ; ^a ; Tamara Djuri&#263 ; ^a ; Aleksandra Stankovi&#263 ; ^a ; Evica Din&#269 ; i&#263 ; ^b ; Olja Stan&#269 ; i&#263 ; ^a ; Nevena Veljkovi&#263 ; ^c ; Dragan Alavanti&#263 ; ^a ; Maja Ž ; ivkovi&#263 ; ^a ; ^{majaz@vinca.rs}
• 关键词：CX3CR1 ; Polymorphism ; V249I ; T280M ; Haplotypes ; Multiple sclerosis ; Clinical course
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：April, 2012
• 卷：245
• 期：1-2
• 页码：87-92
• 文件大小：296 K

摘要

We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I₂₄₉T₂₈₀ haplotype was significantly lower in SP compared to RR patients (RR > 10 years, OR = 0.30, 95%CI = 0.11-0.79, p = 0.01; OR = 0.53, 95%CI = 0.18-1.56, p = 0.2, in SP < 10 years vs. RR > 10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I₂₄₉T₂₈₀ haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results.