Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus

详细信息	查看全文 | 推荐本文 |

• 作者：Shinjiro Miyake^a ; ¹ ; ^{miyake@kdcnet.ac.jp} ; Gota Yoshikawa^a ; ¹ ; Kentaro Yamada^b ; Ken-ichi Sasaguri^a ; Toshiharu Yamamoto^c ; Minoru Onozuka^b ; Sadao Sato^a
• 关键词：HPA ; hypothalamic-pituitary-adrenal ; ACTH ; adrenocorticotropic hormone ; GR ; glucocorticoid receptor ; MWM ; Morris water maze ; ANOVA ; analysis of variance ; CT ; control ; ST ; stress without chewing ; SC ; stress with chewing ; SC ; CA1 ; cornu ammonis 1 ; PBS ; phos
• 刊名：Brain Research
• 出版年：2012
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：29 March, 2012
• 卷：1446
• 期：Complete
• 页码：34-39
• 文件大小：753 K

摘要

Chewing alters hypothalamic-pituitary-adrenal axis function and improves the ability to cope with stress in rodents. Given that stress negatively influences hippocampus-dependent learning and memory, we aimed to elucidate whether masticatory movements, namely chewing, improve the stress-induced impairment of spatial memory in conjunction with increased hippocampal glucocorticoid receptor expression. Male Sprague-Dawley rats were subjected to restraint stress by immobilization for 2 h: the stress with chewing (SC) group were allowed to chew on a wooden stick during the latter half of the immobilization period, whereas the stress without chewing (ST) group were not allowed to do so. Performance in the Morris water maze test was significantly impaired in the ST group compared with the SC group. Further, the numbers of glucocorticoid receptor immunopositive neurons in the hippocampal cornu ammonis 1 region were significantly lower in the ST group than in the control and SC groups. The control and SC rats showed no significant differences in both the water maze performance and the numbers of glucocorticoid receptor-immunopositive neurons. The immunohistochemical finding correlated with the performance in the water maze test. These results suggest that chewing is a behavioral mechanism to cope with stress by increasing hippocampal glucocorticoid receptor expression.