The effect of transforming growth factor-β1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect

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• 作者：Tielinen ; Laura ; Puolakkainen ; Pauli ; Pohjonen ; Timo ; Rautavuori ; Jorma ; Tö ; rmä ; lä ; Pertti ; et. al.
• 关键词：Transforming growth factor-β ; 1 ; Bone defect ; Poly-ld-lactic acid ; ?-caprolactone ; Viscose cellulose sponge
• 刊名：Biomaterials
• 出版年：2002
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：September, 2002
• 卷：23
• 期：18
• 页码：3817-3823
• 文件大小：485 K

摘要

Transforming growth factor-beta 1 (TGF-β1)is a polypeptide growth factor which has been shown to increase bone formation in experimental studies. In this study it was combined to a bioabsorbable self-reinforced poly-ld-lactic acid fracture fixation pin. To assess the effect of TGF-β1 on the healing of a bone defect, the pins were implanted in the rat distal femur next to a bone defect filled with a viscose cellulose sponge. The pins used in the study group (13 rats) contained 50μg of TGF-β1, whereas in the control group of nine rats an identical pin without the growth factor was used. In the histologic examination at 1, 3 and 6 weeks no difference was detected in the amount of bone inside the viscose cellulose sponge between the rats treated with TGF-β1 and those with no added growth factor. At 3 weeks there was more fibroblast-rich mesenchymal tissue inside the viscose cellulose sponge in the rats treated with TGF-β1. In the radiographic examination at 3 weeks there was an increase in the amount of new periosteal bone on the bone defect in the TGF-β1-treated rats.