The inhibition of Th17 immune response in聽vitro and in聽vivo by the carbosilane dendrimer 2G-NN16

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• 作者：Rafael Gras^a ; ^b ; ^{rgras.hgugm@salud.madrid.org} ; Miguel Relloso^a ; ^{miguel.rellosoc@salud.madrid.org} ; Marí ; a I. Garcí ; a^c ; ^{misabel.garciaga@salud.madrid.org} ; F. Javier de la Mata^b ; ^d ; ^{javier.delamata@uah.es} ; Rafael Gó ; mez^b ; ^d ; ^{rafael.gomez@uah.es} ; Luis A. Ló ; pez-Fern&#225 ; ndez^c ; ^{llopezf.hgugm@salud.madrid.org} ; M. Angeles Muñ ; oz-Fern&#225 ; ndez^a ; ^b ; ^{mmunoz.hgugm@salud.madrid.org}
• 关键词：Th17 ; Carbosilane dendrimer ; Th17 mouse model ; IL17F ; IL17A
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：May, 2012
• 卷：33
• 期：15
• 页码：4002-4009
• 文件大小：881 K

摘要

We evaluated the 2G-NN16-carbosilane dendrimer activities in Th17 response as a potential therapy for Th17 deregulated pathologies. IL17A, IL17F, IL22, IL23 and other interleukins secreted by Th17 cells CD4+ cells were down regulated when cells were cultured in the presence of this dendrimer. Furthermore, IL17F and IL17A protein levels in splenocytes from mice pretreated with 2G-NN16 dendrimer in a Th17 induction mouse model were lower than those corresponding to PBS treated mice. Treatment of mice with 2G-NN16 inhibited the Th17 response causing much more pathogenicity as indicated by the increase in the number of Candida albicans colonies in the kidneys as compared to PBS-treated mice. All these results suggest a potential pharmacological application for this dendrimer in the therapy of Th17-mediated diseases.