RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina

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• 作者：Cristina N. Alonso^a ; ^{crisalon9@yahoo.com.ar} ; Marta S. Gallego^b ; Jorge G. Rossi^c ; Adriana Medina^a ; Patricia L. Rubio^a ; Andrea R. Bernasconi^c ; Pedro A. Zubizarreta^a ; Marí ; a S. Felice^a
• 关键词：Pediatric ; ALL ; RT-PCR ; Recurrent translocations ; Prognosis ; Epidemiology
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：June, 2012
• 卷：36
• 期：6
• 页码：704-708
• 文件大小：296 K

摘要

The present study was performed to establish the prevalence of the recurrent fusion transcripts in Argentinean pediatric patients with acute lymphoblastic leukemia (ALL). A total of 380 newly diagnosed children (including 50 infants and 44 T-ALL) were screened by RT-PCR; the incidence of recurrent rearrangements was: ETV6-RUNX1, 12.9%; TCF3-PBX1, 5.0%; BCR-ABL1, 1.6%; and MLL rearrangements, 10.5%. STIL-TAL1 was detected in 22.7%of T-ALL cases. In B-ALL cases, the pEFS was significantly influenced by the presence of genetic alterations. RT-PCR studies improved patients鈥?stratification and also the overall outcome of children treated in a pediatric hospital from a developing country.