Genetic variation in MMP20 contributes to higher caries experience

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• 作者：Patricia Nivoloni Tannure^a ; ^b ; ^j ; Erika Calvano Kü ; chler^c ; ^j ; Andrea Lips^a ; Marcelo de Castro Costa^a ; Ronir Raggio Luiz^d ; Jose Mauro Granjeiro^e ; Alexandre Rezende Vieira^f ; ^g ; ^h ; ⁱ ; ^{arv11@pitt.edu}
• 关键词：Dental caries ; Matrix metalloproteinases ; Enamelysin ; Polymorphisms ; SNPs ; Genetic susceptibility
• 刊名：Journal of Dentistry
• 出版年：2012
• 期刊代码：152_03005712
• 类别：med
• 出版时间：May, 2012
• 卷：40
• 期：5
• 页码：381-386
• 文件大小：270 K

摘要

Matrix metalloproteinases play an important role during the initial process of enamel development and therefore may play a role in caries.

Objectives

To evaluate the association between MMP20 and caries experience in Brazilian children.

Methods

Eligible unrelated children with or without caries were evaluated using a cohort design. Demographic data and oral health habits were obtained though a questionnaire. Caries data was collected by clinical examination. Genotyping of the selected polymorphism was carried out by real-time PCR from genomic DNA. Allele and genotype frequencies were compared between groups with distinct caries experience and oral health habits.

Results

Of 388 subjects, 161 were caries free children. There were no differences between caries levels and genotype distribution in the total cohort. When ethnic background was considered, differences in genotype distribution were observed in caries free children vs. children with caries in Caucasians (p = 0.03). Differences could also be seen when poor oral hygiene was used to stratify the analysis (p = 0.02). Regression analysis, adjusted for genotype and ethnicity, confirmed that ingestion of sweets between meals increases the risk of presenting carious lesions (p = 0.00001; OR = 2.33; 95%CI 1.53-3.54).

Conclusion

Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits.