- 作者：Julien Paccou ; julienpaccou@yahoo.fr ; Juliette Dewailly ; Bernard Cortet
- 关键词：IGF-1 ; Male idiopathic osteoporosis ; Sex hormones ; Fractures ; Bone mineral density
- 刊名：Joint Bone Spine
- 出版年：2012
- 期刊代码：138_1297319x
- 类别：med
- 出版时间：January, 2012
- 卷：79
- 期：1
- 页码：78-82
- 文件大小：183 K
Introduction
The pathophysiology of male idiopathic osteoporosis (MIO) remains unknown. The aim of this study was to evaluate the involvement of IGF-1 in MIO, and to explore the relationships between bone mineral density and serum levels of IGF-1 and sex hormones.Methods
Inclusion criteria were osteoporosis (T-score < 鈭?.5聽SD) and/or an osteoporotic fracture. The osteoporotic patients were included after an exhaustive work-up to exclude the principal causes of secondary osteoporosis. Serum levels of IGF-1, estradiol, testosterone, SHBG, markers of bone turnover, and bone mineral density were compared between 79聽MIO and 26聽healthy subjects.
Results
A significant reduction in serum IGF-1 was found in MIO patients (p = 0.0189). This remained significant after adjustment for body mass index (BMI). A negative correlation was found between SHBG and serum IGF-1 (r = 鈭?.231, p = 0.048). SHBG levels were higher in osteoporotic patients (p = 0.001). The Free Testosterone Index (FTI, total testosterone/SHBG) (p = 0.002) was also lower in MIO patients. After adjustment for FTI and BMI, a significant association was observed between IGF-1 level and the presence of an osteoporotic fracture, indicating an independent effect of IGF-1 level on fracture risk. The odds ratio (OR) for fracture for each SD decrease in IGF1 level was 1.8 [CI: 1.09-2.96] (p = 0.021).
Conclusion
Our study indicates a decrease in serum IGF-1 levels in MIO. This could be either the cause or the consequence of a disturbance in sex hormone metabolism with increased SHBG serum levels.