Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy

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• 作者：Camilla Luzzago^a ; ^{camilla.luzzago@unimi.it} ; Erika Ebranati^b ; Davide Sassera^a ; Alessandra Lo Presti^c ; Stefania Lauzi^a ; Elena Gabanelli^b ; Massimo Ciccozzi^c ; Gianguglielmo Zehender^b
• 关键词：RNA virus ; Pestivirus ; BVDV genotype 1 ; Phylogeography ; Bayesian methods ; Epidemiology
• 刊名：Infection ; Genetics and Evolution
• 出版年：2012
• 期刊代码：119_15671348
• 类别：med
• 出版时间：March, 2012
• 卷：12
• 期：2
• 页码：324-331
• 文件大小：1079 K

摘要

Bovine viral diarrhea virus (BVDV) is a widespread and economically important pathogen of cattle; genetic typing of BVDV isolates distinguished two species, namely BVDV-1 and BVDV-2. BVDV-1 is the most widespread worldwide and it includes at least 11 subtypes. With the aim of clarifying the routes of circulation of BVDV-1 subtypes in an endemic area and in order to investigate the relationships between the genetic diversity of BVDV and its geographic distribution, a phylogenetic analysis of 5鈥?untranslated region of Italian sequences was performed using a new Bayesian framework allowing the spatial-temporal reconstruction of the evolutionary dynamics of highly variable viruses. Our analyses suggested that different BVDV subtypes entered the North-Eastern part of Italy at different times within a time span between 23 and 7 years ago. The largest virus dispersion occurred between the mid 1990s and the early 2000s. A possible gravity-like dynamic of the infection, originating in larger animal population then following patterns of national commercial-flow, should be hypothesized.