• 作者：Juan Manuel Dí ; ez Piñ ; a^a ; ^{jmdpas@gmail.com} ; Marí ; a Jesú ; s Ferná ; ndez Aceñ ; ero^b ; Marí ; a Jesú ; s Llorente Alonso^c ; Salvador Dí ; az Lobato^d ; Sagrario Mayoralas Alises^e ; Esteban Pé ; rez Rodrí ; guez^d ; Dolores Á ; lvaro Á ; lvarez^a ; Asunció ; n Fló ; rez Horcajada^f ; Raquel Pé ; rez Rojo^a
• 关键词：Factor de necrosis tumoral 伪 ; Inflamació ; n ; Fumadores sanos ; Enfermedad pulmonar obstructiva cró ; nica
• 刊名：Medicina Cl篓陋nica
• 出版年：2012
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：16 June, 2012
• 卷：139
• 期：2
• 页码：47-53
• 文件大小：405 K

Background and objectives

Smoking creates an inflammation that leads to lose of lung function. Tumor necrosis factor alpha (TNF-伪) is a cytokine that plays an important role in the pathogenesis of chronic obstructive pulmonary disease. There is a need to develop methods for an early detection of an impaired lung function in smokers. We aimed to show that smokers have higher levels of TNF-伪 in serum and exhaled breath condensate (EBC). We also analysed the influence of sex, age and weight on TNF-伪, and determined the association between smoking, pulmonary function and TNF-伪.

Patients and methods

Prospective study of smokers and non-smokers without any known disease. Respiratory function tests, EBC and blood samples were performed before smoking cessation. Statistical analysis: SPSS 11.0.

Results

Fifty-one patients (60.8%smokers), 56.9%females, mean age 39.88 years old. Smokers initiated at an age of 15.77 years; the mean of cigarettes/day was 21.68. Significant differences in TNF-伪 serum levels between smokers and non-smokers were observed (P < .043). Differences did not reach significance for EBC. For tobacco consumption data, only age at smoking initiation and serum TNF-伪 levels had a correlation. A significant relation between TNF-伪 serum levels and forced expiratory volume in one second and forced vital capacity was found.

Conclusions

Smokers show higher TNF-伪 levels in serum. Number of years of smoking has an influence on TNF-伪 levels. There is a modest corelation between pulmonary function and plasma TNF-伪 levels, but not for EBC.