• 作者：Emilio Má ; rquez-Contreras^a ; ^b ; ^{emarquezc@papps.org} ; Mariano de la Figuera-Von Wichmann^a ; ^c ; Josep Franch-Nadal^a ; ^d ; Jose Luis Llisterri-Caro^a ; ^e ; Vicente Gil-Guillé ; n^a ; ^f ; José ; Luis Mart&#237 ; n-de Pablos^a ; ^b ; José ; Joaquin Casado-Mart&#237 ; nez^a ; ^b ; Nieves Martell-Claros^a ; ^g
• 关键词：ARA-II ; antagonistas de los receptores de la angiotensina II ; HTA ; hipertensió ; n arterial ; IECA ; inhibidores de la enzima de conversió ; n de la angiotensina ; MEMS ; monitores electró ; nicos de control de la medicació ; n (medication eve
• 刊名：Revista Espa?ola de Cardiolog篓陋a
• 出版年：2012
• 期刊代码：pca308_03008932
• 类别：med
• 出版时间：June, 2012
• 卷：65
• 期：6
• 页码：544-550
• 文件大小：291 K

Introduction and objectives

To assess compliance with treatment inhibit the renin-angiotensin system (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) in uncontrolled hypertension in patients at high cardiovascular risk.

Methods

Prospective, longitudinal, multicenter study, carried out in 102 Spanish primary care centers. We included 808 uncontrolled hypertensive patients treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers who were at high vascular risk; 4 visits were conducted: baseline and 1, 3, and 6 months later. Compliance was measured by electronic monitors. We calculated the mean percentage compliance, the overall percentage of compliers, once-daily compliers, compliers with the prescribed time frame, and antihypertensive coverage. We considered a patient to be a complier when the percentage compliance was 80%-100%.

Results

In all, 701 patients completed the study (mean age, 63.7 [11.1] years). The systolic and diastolic blood pressures decreased significantly (P<.0001) to 18.8 mmHg and 9.8聽mmHg, respectively. The control rate was 70%(95%confidence interval, 65.6%-74.4%) (P=.0001). The rate of control was significantly higher among compliers than noncompliers (P<.05). The mean percentage of doses taken was 87.9%(95%confidence interval, 84.8%-91%) and the mean therapeutic coverage was 82.4%(95%confidence interval, 78.7%-86.1%). Overall, 73.3%of the patients were compliers (95%confidence interval, 69%-77.6%), 52.8%(95%confidence interval, 48%-57.6%) were once-daily compliers, and 46.5%(95%confidence interval, 41.9%-51.1%) complied with the prescribed time frame. Noncompliance was associated with a higher number of drugs prescribed (P<.001).

Conclusions

In hypertensive patients at high vascular risk, the rate of therapeutic noncompliance was very high, mainly when they took 5 or more pills daily.

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