Determining germinal centre B cell fate

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• 作者：Dimitra Zotos¹ ; ² ; David M. Tarlinton¹ ; ² ; ^{tarlinton@wehi.edu.au}
• 关键词：memory ; antibodies ; affinity maturation ; humoral immunity ; cytokines
• 刊名：Trends in Immunology
• 出版年：2012
• 期刊代码：257_14714906
• 类别：med
• 出版时间：June, 2012
• 卷：33
• 期：6
• 页码：281-288
• 文件大小：363 K

摘要

The humoral immune system generates immunological memory comprising affinity matured, long-lived memory B cells and plasma cells (PCs), which are generated primarily in germinal centres (GCs). Although many factors are essential in this process, those that specifically govern B cell fate are not fully understood. The provision of T cell help to B cells is key in GC B cell fate determination, and it has become clear recently that this help involves more than direct cell-cell interactions. Recently, the cytokine interleukin (IL)-21 has been identified as a key factor that can modulate the processes within GCs and directly influence B cell fate. In this review, we examine the roles of GC cytokines in the context of cell differentiation.