The use of hormonal contraceptive agents and mood disorders in women

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• 作者：Gjertrud Svendal^a ; ^b ; Michael Berk^c ; ^d ; ^e ; ^f ; Julie A. Pasco^g ; ^h ; Felice N. Jacka^c ; ^d ; Anders Lund^a ; ^b ; Lana J. Williams^c ; ^d ; ^{lanaw@barwonhealth.org.au}
• 关键词：Mood disorders ; Contraceptive agents ; Progestogen ; Estrogen ; Hormones ; Depression
• 刊名：Journal of Affective Disorders
• 出版年：2012
• 期刊代码：141_01650327
• 类别：med
• 出版时间：September, 2012
• 卷：140
• 期：1
• 页码：92-96
• 文件大小：675 K

摘要

Background

Mood disorders are a major cause of disability in developed countries, and contraceptive agents among the most widely used medications. The relationship between contraceptive agents and mood is unclear. The aim of this study was therefore to investigate the association between current contraception use and mood disorders in a random population-based sample of women.

Methods

This study examined epidemiological data obtained from 498 women aged 20-50 year participating in the Geelong Osteoporosis Study (GOS). Mood disorders were diagnosed using a clinical interview (SCID-I/NP) and information on medication use and other lifestyle factors were documented.

Results

After adjusting for age and socioeconomic status (SES), women taking progestin-only contraceptive agents had an increased likelihood of a current mood disorder (OR 3.0 95%CI: 1.1-7.8, p = 0.03). In contrast, women taking combined contraceptive agents had a decreased likelihood of a current mood disorder, adjusting this for age and SES (OR 0.3 95%CI: 0.1, 0.9 p = 0.03). These findings were not explained by weight, physical activity level, past depression, number of medical conditions or cigarette smoking.

Limitations

This study is cross-sectional, which precludes any determination regarding the direction of the relationships.

Conclusions

These data suggest a protective effect of the combined contraceptive pill, and a deleterious effect of progestin only agents in regards to mood disorders.