Properties and potential medical applications of regenerated casein fibers crosslinked with citric acid

详细信息	查看全文 | 推荐本文 |

• 作者：Yiqi Yang^a ; ^b ; ^c ; Narendra Reddy^a ; ^{nreddy3@unl.edu}
• 关键词：Protein fibers ; Casein ; Biocompatibility ; Crosslinking
• 刊名：International Journal of Biological Macromolecules
• 出版年：2012
• 期刊代码：62_01418130
• 类别：abs
• 出版时间：July-August, 2012
• 卷：51
• 期：1-2
• 页码：37-44
• 文件大小：836 K

摘要

Regenerated protein fibers developed from casein using alkaline solutions and crosslinked with citric acid have good tensile properties and water stability but were cytotoxic. Casein is obtained as a byproduct during skim milk production but has limited industrial applications. In this research, casein was dissolved using alkaline solutions and the effects of fiber formation conditions on the tensile properties was studied before and after crosslinking with citric acid. Crosslinked casein fibers had tensile strength as high as 110 MPa and breaking elongation of 13.6%. The fibers were also stable in 90 掳C water between pH 3 and 9 but were hydrolyzed at pH 11. Casein was cytotoxic and did not support the attachment and growth of mouse fibroblasts.