Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells

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• 作者：Pedro Melillo de Magalhã ; es^a ; ^b ; Isabelle Dupont^a ; Auré ; lie Hendrickx^a ; Auré ; lie Joly^a ; Thomas Raas^a ; Sté ; phanie Dessy^c ; Thé ; rè ; se Sergent^a ; Yves-Jacques Schneider^a ; ^{yjs@uclouvain.be}
• 关键词：Artemisia annua ; Artemisinin ; Caco-2 cells ; CYPs ; Intestinal inflammation ; Phenolic compounds ; Rosmarinic acid
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：15 September, 2012
• 卷：134
• 期：2
• 页码：864-871
• 文件大小：503 K

摘要

In an attempt to understand the beneficial health effects of Artemisia annua other than its anti-malaria properties, extracts from different cultivars prepared as tea infusions were investigated using Caco-2 cells on the intestinal inflammation and cytochrome P450 (CYP) activities. The characterisation of their phenolic compound (PC) profile revealed rosmarinic and chlorogenic acids as the main PCs. The extracts, assayed on Caco-2 cells at a plausible intestinal concentration, significantly decreased the secretion of pro-inflammatory cytokines, IL-8 and IL-6. This effect could be attributable at least to their content in rosmarinic acid, detected as a potent anti-inflammatory compound. The extracts also inhibited the activity of CYP3A4, whose expression was induced by 1,25-dihydroxyvitamin D₃, and of CYP1A1, induced by benzo(a)pyrene. Our results highlight the advantage of drinking A. annua infusions for their potent anti-inflammatory effect, linked to PC content, which could synergise their antimalarial activity.