Association between interleukin-6 gene 鈭?#xa0;174 G/C polymorphism and the risk of coronary heart disease: A meta-analysis of 20 studies including 9619 cases and 10,919 controls

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• 作者：Yan-wei Yin^a ; ^{shuaishuaijita@sohu.com} ; Ai-min Hu^a ; Qian-qian Sun^b ; Hong-li Liu^a ; Qi Wang^a ; Yi-hua Zeng^a ; Rui-jia Xu^a ; Zhi-zhen Hou^a ; Zhong-dong Zhang^a ; Shi-jie Zhang^a ; Ming-qi Zhou^a
• 关键词：CHD ; coronary heart disease ; IL-6 ; interleukin-6 ; OR ; odds ratio ; CI ; confidence interval ; NOS ; Newcastle&ndash ; Ottawa Scale ; MI ; myocardial infarction ; HWE ; Hardy&ndash ; Weinberg equilibrium
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：15 July, 2012
• 卷：503
• 期：1
• 页码：25-30
• 文件大小：810 K

摘要

Interleukin-6 (IL-6) gene 鈭?#xA0;174 G/C polymorphism has been reported to be associated with coronary heart disease (CHD), but the results remain inconclusive. The present meta-analysis was therefore designed to clarify these controversies. This meta-analysis was performed by searching PubMed, Embase and Web of Science databases. A total of 20 studies including 9619 CHD cases and 10,919 controls were combined showing no evidence of association between IL-6 gene 鈭?#xA0;174 G/C polymorphism and CHD risk (for C/C + C/G vs. G/G: OR = 1.10, 95%CI = 0.99-1.22, p = 0.07; for C/C vs. C/G + G/G: OR = 1.08, 95%CI = 0.93-1.24, p = 0.33; for C/C vs. G/G: OR = 1.16, 95%CI = 0.97-1.39, p = 0.11; for C allele vs. G allele: OR = 1.10, 95%CI = 1.00-1.21, p = 0.06). Moreover, we also did not find significant association between IL-6 gene 鈭?#xA0;174 G/C polymorphism and myocardial infarction (MI) risk. However, in the subgroup analysis by ethnicity, significant association was found among Asians (for C/C + C/G vs. G/G: OR = 1.35, 95%CI = 1.05-1.63, p = 0.02). In summary, the present meta-analysis suggests that IL-6 gene 鈭?#xA0;174 G/C polymorphism is associated with increased CHD risk among Asians. However, due to the small subjects included in the subgroup analysis of Asians, the results should be interpreted with caution.