Differences in protein fraction from goat and cow milk and their role on cytokine production in children with cow's milk protein allergy

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• 作者：M. Albenzio^a ; ^{m.albenzio@unifg.it} ; A. Campanozzi^b ; M. D&rsquo ; Apolito^b ; A. Santillo^a ; M. Pettoello Mantovani^b ; A. Sevi^a
• 关键词：Goat milk ; Protein fraction ; Milk allergy ; Cytokine
• 刊名：Small Ruminant Research
• 出版年：2012
• 期刊代码：94_09214488
• 类别：abs
• 出版时间：June, 2012
• 卷：105
• 期：1-3
• 页码：202-205
• 文件大小：189 K

摘要

Garganica goat milk was characterized for protein composition and the impact of milk protein mixture, casein and 尾-lactoglobulin fraction on cytokine production by cultured peripheral blood mononuclear cells from infants with cow's milk protein allergy. Bulk milk samples were collected in a dairy goat farm located in the Gargano area (Southern Italy), cow milk was used as control. Ten patients with cow's milk protein allergy (6 males; mean age 8.4 卤 6.4 months) and ten non-allergic control subjects (6 males; mean age 7.4 卤 3.1 months) were consecutively included in the study. Although the amount of total casein was comparable in cow and goat milk (56.08%vs. 55.33%, respectively) the distribution of principal casein fractions was different according to species. 伪-CN on total casein was more than 50%both in raw and pasteurized cow milk whereas it was always lower than 40%in goat milk and an opposite trend was observed for 尾-CN. Production of tumor necrosis factor-伪 after exposure to goat milk casein and 尾-lactoglobulin was lower than after exposure to the same fractions from cow milk. Goat milk induced higher levels of regulatory interleukin-10 by peripheral blood mononuclear cells than cow milk. Results on tumor necrosis factor-伪 evidenced that it is important to test the immune reactivity against each protein fraction before considering goat milk as a safe substitute for feeding infant with cow's milk protein allergy.