Fac-tricarbonyl(pentylcarbonato)(伪-diimine)rhenium complexes: One-pot synthesis, characterization, fluorescence studies, and cytotoxic activity against human MDA-MB-231 breast, CCl-227 colon and BxPC-3 pancreatic carcinoma cell lines

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• 作者：Michael K. Mbagu^a ; ^{mmbagu@gmail.com} ; Divine N. Kebulu^a ; ^{kndode@yahoo.com} ; Angela Winstead^a ; ^{angela.winstead@morgan.edu} ; Saroj K. Pramanik^b ; ^{sarojpramanik@yahoo.ca} ; Hirendra N. Banerjee^c ; ^{bhirendranath@mail.ecsu.edu} ; Maurice O. Iwunze^a ; ^{maurice.iwunze@morgan.edu} ; James M. Wachira^b ; ^{james.wachira@morgan.edu} ; George E. Greco^d ; ^{ggreco@goucher.edu} ; Gregory K. Haynes^a ; ^{gregory.haynes@morgan.edu} ; Amanda Sehmer^e ; ^{sehmera@karmanos.org} ; Fazlul H. Sarkar^f ; ^{fsarkar@med.wayne.edu} ; Douglas M. Ho^g ; ^{doug32009@gmail.com} ; Robert D. Pike^h ; ^{rdpike@wm.edu} ; Santosh K. Mandal^a ; ^{santosh.mandal@gmail.com}
• 关键词：Fac-tricarbonyl(pentylcarbonato)(伪-diimine)rhenium complexes ; X-ray ; Fluorescence ; BxPC-3 pancreatic cancer cell lines ; CCL-227 colon cancer cell lines ; MDA-MB-231 breast cancer cell lines
• 刊名：Inorganic Chemistry Communications
• 出版年：2012
• 期刊代码：39_13877003
• 类别：ch
• 出版时间：July, 2012
• 卷：21
• 期：Complete
• 页码：35-38
• 文件大小：412 K

摘要

A series of pentylcarbonato complexes of the general formula fac-(CO)₃(伪-diimine)ReOC(O)O(CH₂)₄CH₃ (1-7) was synthesized from the reactions of Re₂(CO)₁₀ with the corresponding 伪-diimines in refluxed 1-pentanol while CO₂ was bubbled through the solutions. The 伪-diimines in 1-7 are 2,2鈥?bipyridyl, 1,10-phenanthroline, 5-methyl-1,10-phenanthroline, neocuproin, 5,6-dimethyl-1,10-phenanthroline, bathophenanthroline, and bathocuproin, respectively. Complexes 1-7 have been characterized spectroscopically and by elemental analyses. Additionally, 1 and 6 have been characterized in the solid state by X-ray crystallography. The electronic absorption spectra of 1-7 exhibit metal-to-ligand charge-transfer (MLCT) absorption maxima in the range 343-371 nm in acetonitrile. The emission maxima range from 513 to 532 nm. The average life-time and quantum yield are 1.074 ns and 0.011 respectively. Cytotoxicity studies using a few of these pentylcarbonato complexes reveal that the complexes are cytotoxic against BxPC-3 pancreatic, CCL-227 colon, and MDA-MB-231 breast cancer cell lines.