Association of interleukin 1尾 polymorphisms and haplotypes with Alzheimer's disease

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• 作者：Spencer Luiz Marques Payã ; o^a ; ^d ; ^{slmpayao@famema.br} ; Gisela Moraes Gonç ; alves^a ; Roger William de Labio^d ; Lie Horiguchi^d ; Igor Mizumoto^d ; Lucas Trevizani Rasmussen^d ; Marcela Augusta de Souza Pinhel^e ; Doroté ; ia Rossi Silva Souza^e ; Marcelo Dib Bechara^f ; Elizabeth Chen^b ; Diego Robles Mazzotti^b ; Paulo Henrique Ferreira Bertolucci^c ; Marí ; lia de Arruda Cardoso Smith^b
• 关键词：Alzheimer's disease ; Interleukin-1尾 ; Polymorphisms ; Haplotypes ; Receptor antagonist
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：15 June, 2012
• 卷：247
• 期：1-2
• 页码：59-62
• 文件大小：168 K

摘要

Our study aimed to associate IL-1尾 and IL-1RN polymorphisms with AD disease in comparison with elderly control group from S茫o Paulo 鈥?Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and 鈭?11C > T and 鈭?#xA0;31T > C (IL-1尾) polymorphisms. Our findings revealed that 鈭?#xA0;511C/鈭?#xA0;31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p = 0.005), whereas 鈭?#xA0;511C/鈭?#xA0;31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p = 0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.