• 作者：P&eacute ; p&eacute ; Mfutu Ekulu^a ; ^{drmfutu@yahoo.fr} ; Nazaire Mangani Nseka^b ; Michel Ntetani Aloni^a ; Jean-Lambert Ehungu Gini^a ; Jean-Robert Makulo^b ; Franç ; ois Bompeka Lepira^b ; Ernest Kiswaya Sumaili^b ; Eric Musalu Mafuta^c ; Celestin Ndosimao Nsibu^a ; Joseph Diayisu Shiku^a
• 关键词：Pr&eacute ; valence ; Prot&eacute ; inurie ; Enfants infect&eacute ; s par le VIH ; Kinshasa
• 刊名：N&eacute ; phrologie Th&eacute ; rapeutique
• 出版年：2012
• 期刊代码：227_17697255
• 类别：med
• 出版时间：June, 2012
• 卷：8
• 期：3
• 页码：163-167
• 文件大小：271 K

Context

In Sub-Saharian Africa, the extent of the HIV-related kidney diseases is less known. Even so, that region is supposed to be the epicentre of such complications. This study aimed to determine the prevalence of proteinuria in Congolese children living in Kinshasa and to study its association with the HIV infection.

Methods

By a cross-sectional and multicentric study (in six hospitals of Kinshasa), 194 children were consecutively recruited from August 2008 to February 2009. Among these, 101 naives HIV-infected children and 93 HIV-uninfected children like a control group. Proteinuria was assessed using urine dipstick completed by the 24-hour proteinuria assessment (Esbach method). Determinants of proteinuria were assessed by logistic regression.

Results

The median age of all children recruited was 84 months (9-221months). Concerning the HIV-infected children, the median age was 76 months (9-221months) with a male/female ratio of 1/1. The prevalence of proteinuria in this group was in order to 23.8%. HIV infected children have seven times more probability to present proteinuria than non infected children (OR 6.9; IC 95%: 2.3-20.8; P < 0.001). Important immunosuppression was the main determinant of proteinuria (OR 10.4; IC 95%: 3.34-32.48; P < 0.001).

Conclusion

Proteinuria is common in Congolese children. The HIV infection rises significantly the probability to present proteinuria in children of this study, more so among those with important immunosuppression. This raises the question about the ideal time to initiate HAART in order to reduce the prevalence of kidney injury and to provide the best outcome.