Stereoselective total synthesis of (+)-(6R,2鈥?span style='font-style: italic'>S)-cryptocaryalactone and (鈭?-(6S,2鈥?span style='font-style: italic'>S)-epi cryptocaryalactone via asymmetric acetate aldol reaction
摘要
The total synthesis of (+)-(6R,2鈥?em>S)-cryptocaryalactone and (鈭?-(6S,2鈥?em>S)-epi cryptocaryalactone is reported based on asymmetric acetate aldol reaction. Still-Gennari reaction, Evans acetal intramolecular oxa-Michael reaction and lactonisation are the key steps in the target synthesis.